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Protein Science : a Publication of the Protein Society|January 21, 2026
Cryo-EM reveals an ensemble of cytochrome P450 reductase conformations in solutionGalina I Lepesheva, Tatiana Y Hargrove, Yi Ren
The Journal of Biological Chemistry|June 5, 2020
A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysisTatiana Y Hargrove, Zdzislaw Wawrzak, F Peter Guengerich, et al.
Journal of Medicinal Chemistry|October 31, 2019
Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible InhibitorsLaura Friggeri, Tatiana Y Hargrove, Zdzislaw Wawrzak, et al.
The Journal of Biological Chemistry|August 14, 2015
Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal DrugsTatiana Y Hargrove, Zdzislaw Wawrzak, David C Lamb, et al.
Angewandte Chemie (International Ed. in English)|January 11, 2024
Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-DemethylationKevin D McCarty, Yasuhiro Tateishi, Tatiana Y Hargrove, et al.
The Journal of Biological Chemistry|June 3, 2011
Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantumTatiana Y Hargrove, Zdzislaw Wawrzak, Jialin Liu, et al.
Journal of Lipid Research|December 3, 2011
Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Delta7-24, 25-dihydrolanosterolTatiana Y Hargrove, Zdzislaw Wawrzak, Jialin Liu, et al.
Scientific Reports|September 28, 2022
Unravelling the role of transient redox partner complexes in P450 electron transfer mechanicsTatiana Y Hargrove, David C Lamb, Jarrod A Smith, et al.
The Journal of Biological Chemistry|May 20, 2023
Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1Kevin D McCarty, Molly E Sullivan, Yasuhiro Tateishi, et al.
Journal of Medicinal Chemistry|November 29, 2021
Relaxed Substrate Requirements of Sterol 14α-Demethylase from <i>Naegleria fowleri</i> Are Accompanied by Resistance to InhibitionTatiana Y Hargrove, Zdzislaw Wawrzak, Girish Rachakonda, et al.
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