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ACS Chemical Biology
|
September 16, 2024
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96
Randa Mahran, Jonas N Kapp, Salla Valtonen, et al.
ACS Medicinal Chemistry Letters
|
October 18, 2019
Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks
Fabian Heider, Tatu Pantsar, Mark Kudolo, et al.
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|
July 9, 2017
Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors
Tatu Pantsar, Prosanta Singha, Tapio J Nevalainen, et al.
Journal of Medicinal Chemistry
|
July 2, 2021
Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors
Stanislav Andreev, Tatu Pantsar, Roberta Tesch, et al.
International Journal of Molecular Sciences
|
October 27, 2020
Discovery and Evaluation of Enantiopure 9<i>H</i>-pyrimido[4,5-<i>b</i>]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability
Stanislav Andreev, Tatu Pantsar, Ahmed El-Gokha, et al.
Journal of Medicinal Chemistry
|
September 23, 2022
Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation
Alp Bayrak, Florian Mohr, Kyra Kolb, et al.
Chemistry & Biology
|
March 26, 2013
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase
Niina Aaltonen, Juha R Savinainen, Casandra Riera Ribas, et al.
Nature Medicine
|
May 24, 2016
A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer
Daniel Dauch, Ramona Rudalska, Giacomo Cossa, et al.
Nature Cancer
|
January 17, 2025
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer
Ramona Rudalska, Jule Harbig, Michael Forster, et al.
Biorxiv : the Preprint Server for Biology
|
April 25, 2024
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
Marwah Karim, Manjari Mishra, Chieh-Wen Lo, et al.
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Search research articles
Search
Showing results (21-30 of 31) with videos related to
Sort By:
Page
of 4
ACS Chemical Biology
|
September 16, 2024
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96
Randa Mahran, Jonas N Kapp, Salla Valtonen, et al.
ACS Medicinal Chemistry Letters
|
October 18, 2019
Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks
Fabian Heider, Tatu Pantsar, Mark Kudolo, et al.
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|
July 9, 2017
Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors
Tatu Pantsar, Prosanta Singha, Tapio J Nevalainen, et al.
Journal of Medicinal Chemistry
|
July 2, 2021
Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors
Stanislav Andreev, Tatu Pantsar, Roberta Tesch, et al.
International Journal of Molecular Sciences
|
October 27, 2020
Discovery and Evaluation of Enantiopure 9<i>H</i>-pyrimido[4,5-<i>b</i>]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability
Stanislav Andreev, Tatu Pantsar, Ahmed El-Gokha, et al.
Journal of Medicinal Chemistry
|
September 23, 2022
Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation
Alp Bayrak, Florian Mohr, Kyra Kolb, et al.
Chemistry & Biology
|
March 26, 2013
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase
Niina Aaltonen, Juha R Savinainen, Casandra Riera Ribas, et al.
Nature Medicine
|
May 24, 2016
A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer
Daniel Dauch, Ramona Rudalska, Giacomo Cossa, et al.
Nature Cancer
|
January 17, 2025
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer
Ramona Rudalska, Jule Harbig, Michael Forster, et al.
Biorxiv : the Preprint Server for Biology
|
April 25, 2024
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
Marwah Karim, Manjari Mishra, Chieh-Wen Lo, et al.
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of 4