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ACS Medicinal Chemistry Letters
|
June 6, 2014
Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design
Hengmiao Cheng, Chunze Li, Simon Bailey, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 2, 2010
Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK
Steven P Tanis, Michael B Plewe, Ted W Johnson, et al.
The New England Journal of Medicine
|
December 25, 2015
Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
Alice T Shaw, Luc Friboulet, Ignaty Leshchiner, et al.
Journal of Medicinal Chemistry
|
March 31, 2011
Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors
Ted W Johnson, Steven P Tanis, Scott L Butler, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
March 4, 2015
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations
Helen Y Zou, Qiuhua Li, Lars D Engstrom, et al.
Nature Cancer
|
June 21, 2022
Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer
Aya Shiba-Ishii, Ted W Johnson, Ibiayi Dagogo-Jack, et al.
Neuro-Oncology
|
September 26, 2015
CNS Anticancer Drug Discovery and Development Conference White Paper
Victor A Levin, Peter J Tonge, James M Gallo, et al.
Cancer Discovery
|
April 14, 2018
Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound <i>ALK</i> Mutations in ALK-Positive Lung Cancer
Satoshi Yoda, Jessica J Lin, Michael S Lawrence, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|
March 9, 2021
Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in <i>ROS1</i> Fusion-Positive Lung Cancer
Jessica J Lin, Noura J Choudhury, Satoshi Yoda, et al.
Cancer Cell
|
July 7, 2015
PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models
Helen Y Zou, Luc Friboulet, David P Kodack, et al.
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Search research articles
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Showing results (11-20 of 25) with videos related to
Sort By:
Page
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ACS Medicinal Chemistry Letters
|
June 6, 2014
Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design
Hengmiao Cheng, Chunze Li, Simon Bailey, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 2, 2010
Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK
Steven P Tanis, Michael B Plewe, Ted W Johnson, et al.
The New England Journal of Medicine
|
December 25, 2015
Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
Alice T Shaw, Luc Friboulet, Ignaty Leshchiner, et al.
Journal of Medicinal Chemistry
|
March 31, 2011
Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors
Ted W Johnson, Steven P Tanis, Scott L Butler, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
March 4, 2015
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations
Helen Y Zou, Qiuhua Li, Lars D Engstrom, et al.
Nature Cancer
|
June 21, 2022
Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer
Aya Shiba-Ishii, Ted W Johnson, Ibiayi Dagogo-Jack, et al.
Neuro-Oncology
|
September 26, 2015
CNS Anticancer Drug Discovery and Development Conference White Paper
Victor A Levin, Peter J Tonge, James M Gallo, et al.
Cancer Discovery
|
April 14, 2018
Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound <i>ALK</i> Mutations in ALK-Positive Lung Cancer
Satoshi Yoda, Jessica J Lin, Michael S Lawrence, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|
March 9, 2021
Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in <i>ROS1</i> Fusion-Positive Lung Cancer
Jessica J Lin, Noura J Choudhury, Satoshi Yoda, et al.
Cancer Cell
|
July 7, 2015
PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models
Helen Y Zou, Luc Friboulet, David P Kodack, et al.
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