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Bioorganic & Medicinal Chemistry|June 29, 2011
Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)Wen-Hsing Lin, Shu-Yi Hsieh, Shih-Chieh Yen, et al.Journal of Medicinal Chemistry|December 7, 2010
Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetesChun-Hsu Yao, Jen-Shin Song, Chiung-Tong Chen, et al.Bioorganic & Medicinal Chemistry Letters|May 21, 2010
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IVTeng-Kuang Yeh, Ting-Yueh Tsai, Tsu Hsu, et al.Bioconjugate Chemistry|June 6, 2017
Targeting Tumor Associated Phosphatidylserine with New Zinc Dipicolylamine-Based Drug ConjugatesYu-Wei Liu, Kak-Shan Shia, Chien-Huang Wu, et al.Journal of Medicinal Chemistry|January 22, 2020
Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase InhibitorsYi-Hui Peng, Fang-Yu Liao, Chen-Tso Tseng, et al.Bioorganic & Medicinal Chemistry|April 27, 2013
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)Wen-Hsing Lin, John T-A Hsu, Shu-Yi Hsieh, et al.Journal of Medicinal Chemistry|November 26, 2024
Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological CharacterizationHsin-Huei Chang, Lung-Chun Lee, Tsu Hsu, et al.Journal of Medicinal Chemistry|June 18, 2009
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO miceChien-Huang Wu, Ming-Shiu Hung, Jen-Shin Song, et al.ACS Medicinal Chemistry Letters|December 21, 2016
Bromomethylthioindole Inspired Carbazole Hybrids as Promising Class of Anti-MRSA AgentsChia-Yi Cheng, Chun-Ping Chang, Tsai-Ling Yang Lauderdale, et al.Journal of Medicinal Chemistry|May 19, 2021
Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC OncoproteinsYa-Hui Chi, Teng-Kuang Yeh, Yi-Yu Ke, et al.Pageof 13