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Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|June 11, 2009
Targeting NEDD8-activated cullin-RING ligases for the treatment of cancerTeresa A Soucy, Peter G Smith, Mark RolfeGenes & Cancer|July 23, 2011
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and TherapyTeresa A Soucy, Lawrence R Dick, Peter G Smith, et al.Cancer Research|April 14, 2011
Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnoverMichael A Milhollen, Usha Narayanan, Teresa A Soucy, et al.Cell Biochemistry and Biophysics|June 12, 2013
Absolute quantification of E1, ubiquitin-like proteins and Nedd8-MLN4924 adduct by mass spectrometryXiaofeng Yang, James E Brownell, Qing Xu, et al.The Biochemical Journal|July 17, 2010
Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunitChristopher Blackburn, Kenneth M Gigstad, Paul Hales, et al.Blood|June 8, 2010
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphomaMichael A Milhollen, Tary Traore, Jennifer Adams-Duffy, et al.Molecular Cell|February 5, 2010
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situJames E Brownell, Michael D Sintchak, James M Gavin, et al.Nature|April 11, 2009
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerTeresa A Soucy, Peter G Smith, Michael A Milhollen, et al.Pageof 1