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Journal of Lipid Research|March 21, 2008
Plasma PCSK9 preferentially reduces liver LDL receptors in miceAldo Grefhorst, Markey C McNutt, Thomas A Lagace, et al.
The Journal of Biological Chemistry|February 13, 2013
Low density lipoprotein binds to proprotein convertase subtilisin/kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein receptor degradationTanja Kosenko, Mia Golder, Geoffrey Leblond, et al.
Atherosclerosis|June 26, 2020
Molecular mechanism linking a novel PCSK9 copy number variant to severe hypercholesterolemiaPaulina Lau, Sébastien Soubeyrand, Robert A Hegele, et al.
European Journal of Medicinal Chemistry|February 14, 2015
LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153-421): design, synthesis and biochemical evaluationRasha H Alghamdi, Paul O'Reilly, Chunyu Lu, et al.
Proceedings of the National Academy of Sciences of the United States of America|February 6, 2008
Molecular basis for LDL receptor recognition by PCSK9Hyock Joo Kwon, Thomas A Lagace, Markey C McNutt, et al.
The Journal of Clinical Endocrinology and Metabolism|April 9, 2009
Genetic and metabolic determinants of plasma PCSK9 levelsSusan G Lakoski, Thomas A Lagace, Jonathan C Cohen, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology|June 17, 2021
A Common Polymorphism in the <i>FADS1</i> Locus Links miR1908 to Low-Density Lipoprotein Cholesterol Through BMP1Kaitlyn Beehler, Majid Nikpay, Paulina Lau, et al.
The Journal of Biological Chemistry|February 20, 2009
Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cellsMarkey C McNutt, Hyock Joo Kwon, Chiyuan Chen, et al.
Frontiers in Physiology|October 3, 2022
Pathogenic gain-of-function mutations in the prodomain and C-terminal domain of PCSK9 inhibit LDL bindingSamantha K Sarkar, Angela Matyas, Ikhuosho Asikhia, et al.
The Journal of Biological Chemistry|April 25, 2007
Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradationDa-Wei Zhang, Thomas A Lagace, Rita Garuti, et al.
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