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Journal of Medicinal Chemistry|November 18, 2017
Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol LipaseChristopher R Butler, Elizabeth M Beck, Anthony Harris, et al.Journal of Medicinal Chemistry|June 18, 2024
Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine ReceptorChristopher R Butler, Michael Popiolek, Laura A McAllister, et al.Journal of Medicinal Chemistry|February 20, 2015
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug designChristopher R Butler, Michael A Brodney, Elizabeth M Beck, et al.Journal of Medicinal Chemistry|March 3, 2018
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of NeuroinflammationLaura A McAllister, Christopher R Butler, Scot Mente, et al.Journal of Neurology, Neurosurgery, and Psychiatry|March 16, 2021
MRI data-driven algorithm for the diagnosis of behavioural variant frontotemporal dementiaAna L Manera, Mahsa Dadar, John Cornelis Van Swieten, et al.Bioorganic & Medicinal Chemistry Letters|May 20, 2015
Discovery of a novel Kv7 channel opener as a treatment for epilepsyJennifer E Davoren, Michelle M Claffey, Sheri L Snow, et al.Journal of Neurology, Neurosurgery, and Psychiatry|June 12, 2019
Education modulates brain maintenance in presymptomatic frontotemporal dementiaStefano Gazzina, Mario Grassi, Enrico Premi, et al.Journal of Medicinal Chemistry|March 18, 2015
Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitorsMichael A Brodney, Elizabeth M Beck, Christopher R Butler, et al.Journal of Neurology, Neurosurgery, and Psychiatry|August 10, 2020
Early symptoms in symptomatic and preclinical genetic frontotemporal lobar degenerationTamara Paulo Tavares, Derek G V Mitchell, Kristy Kl Coleman, et al.Journal of Medicinal Chemistry|April 4, 2018
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking HypopigmentationBrian T O'Neill, Elizabeth M Beck, Christopher R Butler, et al.Pageof 10