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Nature Communications|September 7, 2021
The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscleThomas Kampourakis, Malcolm IrvingThe Journal of Biological Chemistry|December 16, 2021
Microscale thermophoresis suggests a new model of regulation of cardiac myosin function via interaction with cardiac myosin-binding protein CSaraswathi Ponnam, Thomas KampourakisJournal of Molecular and Cellular Cardiology|June 10, 2015
Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscleThomas Kampourakis, Malcolm IrvingJournal of Molecular and Cellular Cardiology|February 17, 2018
Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscleThomas Kampourakis, Saraswathi Ponnam, Malcolm IrvingBiophysical Journal|January 22, 2015
Orientation of the N- and C-terminal lobes of the myosin regulatory light chain in cardiac muscleThomas Kampourakis, Yin-Biao Sun, Malcolm IrvingBiophysical Reviews|January 20, 2025
Structural changes in troponin during activation of skeletal and heart muscle determined in situ by polarised fluorescenceIvanka R Sevrieva, Thomas Kampourakis, Malcolm IrvingProceedings of the National Academy of Sciences of the United States of America|May 11, 2016
Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filamentsThomas Kampourakis, Yin-Biao Sun, Malcolm IrvingJACC. Advances|April 26, 2025
Cardiac Troponin: Fragments of the Future?Samuel McGrath, Bashir Alaour, Thomas Kampourakis, et al.The Journal of Physiology|October 21, 2017
Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filamentThomas Kampourakis, Xuemeng Zhang, Yin-Biao Sun, et al.ACS Chemical Biology|June 1, 2022
Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7Fangze Cai, Thomas Kampourakis, Kieran T Cockburn, et al.Pageof 4