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Bioorganic & Medicinal Chemistry Letters
|
May 11, 2019
Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249
Yuzo Iwaki, Kentaro Yashiro, Masaya Kokubo, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|
February 28, 2014
M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location
Daniel J Foster, Patrick R Gentry, Jose E Lizardi-Ortiz, et al.
Chemmedchem
|
August 26, 2009
Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor
J Phillip Kennedy, Thomas M Bridges, Patrick R Gentry, et al.
Journal of Medicinal Chemistry
|
May 15, 2009
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins
Thomas M Bridges, Joy E Marlo, Colleen M Niswender, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 28, 2014
Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges
Haruto Kurata, Patrick R Gentry, Masaya Kokubo, et al.
ACS Chemical Neuroscience
|
December 22, 2012
Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode
Gregory J Digby, Thomas J Utley, Atin Lamsal, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|
September 2, 2020
Modulation of arousal and sleep/wake architecture by M<sub>1</sub> PAM VU0453595 across young and aged rodents and nonhuman primates
Robert W Gould, Jason K Russell, Michael T Nedelcovych, et al.
ACS Chemical Neuroscience
|
July 4, 2019
Acute Negative Allosteric Modulation of M<sub>5</sub> Muscarinic Acetylcholine Receptors Inhibits Oxycodone Self-Administration and Cue-Induced Reactivity with No Effect on Antinociception
Robert W Gould, Barak W Gunter, Michael Bubser, et al.
ACS Chemical Neuroscience
|
November 27, 2018
Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models
Kristopher K Abney, Michael Bubser, Yu Du, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 19, 2013
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule
Michael S Poslusney, Bruce J Melancon, Patrick R Gentry, et al.
Page
of 11
Search research articles
Search
Showing results (21-30 of 108) with videos related to
Sort By:
Page
of 11
Bioorganic & Medicinal Chemistry Letters
|
May 11, 2019
Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249
Yuzo Iwaki, Kentaro Yashiro, Masaya Kokubo, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|
February 28, 2014
M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location
Daniel J Foster, Patrick R Gentry, Jose E Lizardi-Ortiz, et al.
Chemmedchem
|
August 26, 2009
Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor
J Phillip Kennedy, Thomas M Bridges, Patrick R Gentry, et al.
Journal of Medicinal Chemistry
|
May 15, 2009
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins
Thomas M Bridges, Joy E Marlo, Colleen M Niswender, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 28, 2014
Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges
Haruto Kurata, Patrick R Gentry, Masaya Kokubo, et al.
ACS Chemical Neuroscience
|
December 22, 2012
Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode
Gregory J Digby, Thomas J Utley, Atin Lamsal, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|
September 2, 2020
Modulation of arousal and sleep/wake architecture by M<sub>1</sub> PAM VU0453595 across young and aged rodents and nonhuman primates
Robert W Gould, Jason K Russell, Michael T Nedelcovych, et al.
ACS Chemical Neuroscience
|
July 4, 2019
Acute Negative Allosteric Modulation of M<sub>5</sub> Muscarinic Acetylcholine Receptors Inhibits Oxycodone Self-Administration and Cue-Induced Reactivity with No Effect on Antinociception
Robert W Gould, Barak W Gunter, Michael Bubser, et al.
ACS Chemical Neuroscience
|
November 27, 2018
Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models
Kristopher K Abney, Michael Bubser, Yu Du, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 19, 2013
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule
Michael S Poslusney, Bruce J Melancon, Patrick R Gentry, et al.
Page
of 11