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Thomas M Bridges

Showing results (31-40 of 108) with videos related to

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ACS Chemical Neuroscience|March 27, 2019
Correction to Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain ModelsKristopher K Abney, Michael Bubser, Yu Du, et al.
Bioorganic & Medicinal Chemistry Letters|December 3, 2019
Discovery of structurally distinct tricyclic M<sub>4</sub> positive allosteric modulator (PAM) chemotypesKayla J Temple, Madeline F Long, Julie L Engers, et al.
Bioorganic & Medicinal Chemistry Letters|October 16, 2012
Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonistsMichael S Poslusney, Christian Sevel, Thomas J Utley, et al.
Bioorganic & Medicinal Chemistry Letters|September 23, 2008
Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moietiesThomas M Bridges, Ashley E Brady, J Phillip Kennedy, et al.
Bioorganic & Medicinal Chemistry Letters|April 9, 2013
Discovery of ML326: The first sub-micromolar, selective M5 PAMPatrick R Gentry, Thomas M Bridges, Atin Lamsal, et al.
Bioorganic & Medicinal Chemistry Letters|December 25, 2018
Novel M<sub>4</sub> positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligandsMichael S Poslusney, James M Salovich, Michael R Wood, et al.
Bioorganic & Medicinal Chemistry Letters|June 22, 2017
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonistsAaron M Bender, Rebecca L Weiner, Vincent B Luscombe, et al.
Bioorganic & Medicinal Chemistry Letters|January 8, 2008
Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonistsL Michelle Lewis, Douglas Sheffler, Richard Williams, et al.
Bioorganic & Medicinal Chemistry Letters|October 18, 2017
Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotype via scaffold hoppingMadeline F Long, Julie L Engers, Sichen Chang, et al.
Bioorganic & Medicinal Chemistry Letters|September 4, 2017
Discovery of a novel, CNS penetrant M<sub>4</sub> PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile coreBlake R Bewley, Paul K Spearing, Rebecca L Weiner, et al.
Pageof 11

Showing results (31-40 of 108) with videos related to

Sort By:
Pageof 11
ACS Chemical Neuroscience|March 27, 2019
Correction to Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain ModelsKristopher K Abney, Michael Bubser, Yu Du, et al.
Bioorganic & Medicinal Chemistry Letters|December 3, 2019
Discovery of structurally distinct tricyclic M<sub>4</sub> positive allosteric modulator (PAM) chemotypesKayla J Temple, Madeline F Long, Julie L Engers, et al.
Bioorganic & Medicinal Chemistry Letters|October 16, 2012
Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonistsMichael S Poslusney, Christian Sevel, Thomas J Utley, et al.
Bioorganic & Medicinal Chemistry Letters|September 23, 2008
Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moietiesThomas M Bridges, Ashley E Brady, J Phillip Kennedy, et al.
Bioorganic & Medicinal Chemistry Letters|April 9, 2013
Discovery of ML326: The first sub-micromolar, selective M5 PAMPatrick R Gentry, Thomas M Bridges, Atin Lamsal, et al.
Bioorganic & Medicinal Chemistry Letters|December 25, 2018
Novel M<sub>4</sub> positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligandsMichael S Poslusney, James M Salovich, Michael R Wood, et al.
Bioorganic & Medicinal Chemistry Letters|June 22, 2017
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonistsAaron M Bender, Rebecca L Weiner, Vincent B Luscombe, et al.
Bioorganic & Medicinal Chemistry Letters|January 8, 2008
Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonistsL Michelle Lewis, Douglas Sheffler, Richard Williams, et al.
Bioorganic & Medicinal Chemistry Letters|October 18, 2017
Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotype via scaffold hoppingMadeline F Long, Julie L Engers, Sichen Chang, et al.
Bioorganic & Medicinal Chemistry Letters|September 4, 2017
Discovery of a novel, CNS penetrant M<sub>4</sub> PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile coreBlake R Bewley, Paul K Spearing, Rebecca L Weiner, et al.
Pageof 11