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Thomas M McGuire

Showing results (21-30 of 32) with videos related to

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Advanced Science (Weinheim, Baden-Wurttemberg, Germany)|June 10, 2025
Recyclable Li-Metal Battery Electrolytes via In Situ Cyclic Carbonate PolymerizationHui Gao, Victor Riesgo-Gonzalez, James R Runge, et al.
Journal of Medicinal Chemistry|December 16, 2022
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for OncologyFrederick W Goldberg, Jason G Kettle, Gillian M Lamont, et al.
Journal of Medicinal Chemistry|February 12, 2013
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activityKevin M Foote, Kevin Blades, Anna Cronin, et al.
ACS Medicinal Chemistry Letters|August 22, 2018
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM InhibitorsBernard Barlaam, Elaine Cadogan, Andrew Campbell, et al.
Bioorganic & Medicinal Chemistry Letters|August 4, 2012
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibitionAlexander G Dossetter, Jonathan Bowyer, Calum R Cook, et al.
Journal of Medicinal Chemistry|September 19, 2012
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitorsJames J Crawford, Peter W Kenny, Jonathan Bowyer, et al.
Journal of Medicinal Chemistry|June 30, 2012
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritisAlexander G Dossetter, Howard Beeley, Jonathan Bowyer, et al.
Journal of Medicinal Chemistry|April 24, 2018
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one)Kurt G Pike, Bernard Barlaam, Elaine Cadogan, et al.
Journal of Medicinal Chemistry|October 14, 2021
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target EngagementBernard Barlaam, Chris De Savi, Allan Dishington, et al.
ACS Medicinal Chemistry Letters|March 28, 2015
Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacologyJeffrey W Johannes, Lynsie Almeida, Bernard Barlaam, et al.
Pageof 4

Showing results (21-30 of 32) with videos related to

Sort By:
Pageof 4
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)|June 10, 2025
Recyclable Li-Metal Battery Electrolytes via In Situ Cyclic Carbonate PolymerizationHui Gao, Victor Riesgo-Gonzalez, James R Runge, et al.
Journal of Medicinal Chemistry|December 16, 2022
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for OncologyFrederick W Goldberg, Jason G Kettle, Gillian M Lamont, et al.
Journal of Medicinal Chemistry|February 12, 2013
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activityKevin M Foote, Kevin Blades, Anna Cronin, et al.
ACS Medicinal Chemistry Letters|August 22, 2018
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM InhibitorsBernard Barlaam, Elaine Cadogan, Andrew Campbell, et al.
Bioorganic & Medicinal Chemistry Letters|August 4, 2012
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibitionAlexander G Dossetter, Jonathan Bowyer, Calum R Cook, et al.
Journal of Medicinal Chemistry|September 19, 2012
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitorsJames J Crawford, Peter W Kenny, Jonathan Bowyer, et al.
Journal of Medicinal Chemistry|June 30, 2012
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritisAlexander G Dossetter, Howard Beeley, Jonathan Bowyer, et al.
Journal of Medicinal Chemistry|April 24, 2018
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one)Kurt G Pike, Bernard Barlaam, Elaine Cadogan, et al.
Journal of Medicinal Chemistry|October 14, 2021
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target EngagementBernard Barlaam, Chris De Savi, Allan Dishington, et al.
ACS Medicinal Chemistry Letters|March 28, 2015
Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacologyJeffrey W Johannes, Lynsie Almeida, Bernard Barlaam, et al.
Pageof 4