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Epidemiologia (Basel, Switzerland)|November 25, 2024
Big Epidemiology: The Birth, Life, Death, and Resurgence of Diseases on a Global TimescaleNicola Luigi Bragazzi, Thorsten Lehr
Pharmaceutics|November 13, 2020
A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug-Drug-Gene Interaction PredictionsDenise Türk, Nina Hanke, Thorsten Lehr
Journal of Chemical Information and Modeling|November 20, 2024
Exploring the Potential of Adaptive, Local Machine Learning in Comparison to the Prediction Performance of Global Models: A Case Study from Bayer's Caco-2 Permeability DatabaseFrank Filip Steinbauer, Thorsten Lehr, Andreas Reichel
Pharmacogenetics and Genomics|June 23, 2010
Integration of high-throughput genotyping data into pharmacometric analyses using nonlinear mixed effects modelingThorsten Lehr, Hans-Guenter Schaefer, Alexander Staab
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences|April 25, 2016
Population pharmacokinetics of ponesimod and its primary metabolites in healthy and organ-impaired subjectsDominik Lott, Andreas Krause, Jasper Dingemanse, et al.
Clinical Pharmacology and Therapeutics|September 16, 2017
Modeling Tolerance Development for the Effect on Heart Rate of the Selective S1P<sub>1</sub> Receptor Modulator PonesimodDominik Lott, Thorsten Lehr, Jasper Dingemanse, et al.
Clinical Pharmacokinetics|September 18, 2016
Impact of Demographics, Organ Impairment, Disease, Formulation, and Food on the Pharmacokinetics of the Selective S1P<sub>1</sub> Receptor Modulator Ponesimod Based on 13 Clinical StudiesDominik Lott, Thorsten Lehr, Jasper Dingemanse, et al.
CPT: Pharmacometrics & Systems Pharmacology|October 2, 2018
A Quantitative Systems Pharmacology Kidney Model of Diabetes Associated Renal Hyperfiltration and the Effects of SGLT InhibitorsPavel Balazki, Stephan Schaller, Thomas Eissing, et al.
CPT: Pharmacometrics & Systems Pharmacology|June 17, 2020
A Physiologically-Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP-1 and GIP and the DPP4 Inhibitor SitagliptinPavel Balazki, Stephan Schaller, Thomas Eissing, et al.
Journal of Clinical Pharmacology|May 29, 2013
A semi-physiological model of amyloid-β biosynthesis and clearance in human cerebrospinal fluid: a tool for alzheimer's disease research and drug developmentKarin G Haug, Alexander Staab, Chantaratsamon Dansirikul, et al.
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