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Journal of Medicinal Chemistry|November 19, 2014
Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activityJon J Hangeland, Todd J Friends, Karen A Rossi, et al.Bioorganic & Medicinal Chemistry Letters|August 26, 2019
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailabilityCharles G Clark, Karen A Rossi, James R Corte, et al.Journal of Medicinal Chemistry|May 28, 2020
Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical SpeciesWu Yang, Yufeng Wang, Amy Lai, et al.Journal of Medicinal Chemistry|September 8, 2021
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic TherapyAndrew K Dilger, Kumar B Pabbisetty, James R Corte, et al.Journal of Medicinal Chemistry|December 14, 2019
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 GroupsJames R Corte, Donald J P Pinto, Tianan Fang, et al.Pageof 2