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Toxicological Sciences : an Official Journal of the Society of Toxicology|May 3, 2025
Dual inhibition of TGFβ2,3 is severely toxic, whereas selective inhibition of TGFβ1, 2, or 3 and dual inhibition of TGFβ1,2 is generally tolerated In mouse and cynomolgus monkey toxicology studiesMayur S Mitra, Wendy Halpern, Michelle Lepherd, et al.The Journal of Experimental Medicine|March 4, 2009
Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral responseAgnieszka Kielczewska, Michal Pyzik, Tianhe Sun, et al.Med (New York, N.Y.)|January 25, 2024
Isoform-selective TGF-β3 inhibition for systemic sclerosisTianhe Sun, Jason A Vander Heiden, Xia Gao, et al.Journal of Pharmaceutical Sciences|July 10, 2023
Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic DiseasesRajbharan Yadav, Siddharth Sukumaran, Jeff Lutman, et al.Cell Reports. Medicine|July 25, 2023
An agonistic anti-signal regulatory protein α antibody for chronic inflammatory diseasesMarkus M Xie, Bingbing Dai, Jason A Hackney, et al.Science Translational Medicine|August 5, 2021
TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesisTianhe Sun, Zhiyu Huang, Wei-Ching Liang, et al.Biorxiv : the Preprint Server for Biology|January 7, 2026
Combined antagonism of Oncostatin M (OSM) and Interleukin 6 (IL-6) provides both anti-fibrotic and anti-inflammatory benefit in pulmonary fibrosisRojo A Ratsimandresy, Emma Doran, Hart S Dengler, et al.Pageof 2