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Tim J Wigle

Showing results (21-30 of 37) with videos related to

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Journal of Medicinal Chemistry|January 16, 2016
The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of TazemetostatKevin W Kuntz, John E Campbell, Heike Keilhack, et al.
Chemical Biology & Drug Design|September 18, 2012
Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1LAravind Basavapathruni, Lei Jin, Scott R Daigle, et al.
Plos One|May 10, 2018
Identification of a peptide inhibitor for the histone methyltransferase WHSC1Michael J Morrison, P Ann Boriack-Sjodin, Kerren K Swinger, et al.
Journal of Medicinal Chemistry|March 23, 2011
Small-molecule ligands of methyl-lysine binding proteinsJ Martin Herold, Tim J Wigle, Jacqueline L Norris, et al.
Plos One|December 11, 2014
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin LymphomasSarah K Knutson, Natalie M Warholic, L Danielle Johnston, et al.
Cell Chemical Biology|July 18, 2020
In Vitro and Cellular Probes to Study PARP Enzyme Target EngagementTim J Wigle, Danielle J Blackwell, Laurie B Schenkel, et al.
ACS Medicinal Chemistry Letters|June 24, 2015
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool CompoundLorna H Mitchell, Allison E Drew, Scott A Ribich, et al.
Chembiochem : a European Journal of Chemical Biology|April 10, 2021
Targeted Degradation of PARP14 Using a Heterobifunctional Small MoleculeTim J Wigle, Yue Ren, Jennifer R Molina, et al.
ACS Medicinal Chemistry Letters|May 26, 2015
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo ActivityJohn E Campbell, Kevin W Kuntz, Sarah K Knutson, et al.
Journal of Medicinal Chemistry|July 10, 2010
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolinesFeng Liu, Xin Chen, Abdellah Allali-Hassani, et al.
Pageof 4

Showing results (21-30 of 37) with videos related to

Sort By:
Pageof 4
Journal of Medicinal Chemistry|January 16, 2016
The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of TazemetostatKevin W Kuntz, John E Campbell, Heike Keilhack, et al.
Chemical Biology & Drug Design|September 18, 2012
Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1LAravind Basavapathruni, Lei Jin, Scott R Daigle, et al.
Plos One|May 10, 2018
Identification of a peptide inhibitor for the histone methyltransferase WHSC1Michael J Morrison, P Ann Boriack-Sjodin, Kerren K Swinger, et al.
Journal of Medicinal Chemistry|March 23, 2011
Small-molecule ligands of methyl-lysine binding proteinsJ Martin Herold, Tim J Wigle, Jacqueline L Norris, et al.
Plos One|December 11, 2014
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin LymphomasSarah K Knutson, Natalie M Warholic, L Danielle Johnston, et al.
Cell Chemical Biology|July 18, 2020
In Vitro and Cellular Probes to Study PARP Enzyme Target EngagementTim J Wigle, Danielle J Blackwell, Laurie B Schenkel, et al.
ACS Medicinal Chemistry Letters|June 24, 2015
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool CompoundLorna H Mitchell, Allison E Drew, Scott A Ribich, et al.
Chembiochem : a European Journal of Chemical Biology|April 10, 2021
Targeted Degradation of PARP14 Using a Heterobifunctional Small MoleculeTim J Wigle, Yue Ren, Jennifer R Molina, et al.
ACS Medicinal Chemistry Letters|May 26, 2015
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo ActivityJohn E Campbell, Kevin W Kuntz, Sarah K Knutson, et al.
Journal of Medicinal Chemistry|July 10, 2010
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolinesFeng Liu, Xin Chen, Abdellah Allali-Hassani, et al.
Pageof 4