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Nature|May 25, 2012
Melanoma genome sequencing reveals frequent PREX2 mutationsMichael F Berger, Eran Hodis, Timothy P Heffernan, et al.Science Translational Medicine|September 3, 2025
An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancerKathleen M McAndrews, Francesca Paradiso, Clint A Stalnecker, et al.Cancer Discovery|December 10, 2015
Loss of PTEN Promotes Resistance to T Cell-Mediated ImmunotherapyWeiyi Peng, Jie Qing Chen, Chengwen Liu, et al.Journal of Medicinal Chemistry|October 29, 2020
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical PropertiesMichael J Soth, Kang Le, Maria Emilia Di Francesco, et al.Cancer Research|September 15, 2020
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward OsimertinibYuting Sun, Brooke A Meyers, Barbara Czako, et al.Nature Medicine|January 19, 2023
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trialsTimothy A Yap, Naval Daver, Mikhila Mahendra, et al.Cancer Discovery|July 8, 2024
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic CancerJulien Dilly, Megan T Hoffman, Laleh Abbassi, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|February 28, 2024
Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor TypesPatrick G Pilié, Virginia Giuliani, Wei-Lien Wang, et al.Nature Medicine|June 13, 2018
An inhibitor of oxidative phosphorylation exploits cancer vulnerabilityJennifer R Molina, Yuting Sun, Marina Protopopova, et al.Nature|June 15, 2022
Androgen receptor blockade promotes response to BRAF/MEK-targeted therapyChristopher P Vellano, Michael G White, Miles C Andrews, et al.Pageof 8