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Journal of Medicinal Chemistry|July 25, 2025
Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo EfficacyJoachim Bröker, Alex G Waterson, Timothy R Hodges, et al.Journal of Medicinal Chemistry|August 5, 2024
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid TumorsJames C Tarr, James M Salovich, Martin Aichinger, et al.Journal of Medicinal Chemistry|March 15, 2021
One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRASJuergen Ramharter, Dirk Kessler, Peter Ettmayer, et al.Journal of Medicinal Chemistry|November 6, 2019
Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase InhibitorsHarald Engelhardt, Dietrich Böse, Mark Petronczki, et al.Cancer Discovery|August 21, 2020
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK InhibitionMarco H Hofmann, Michael Gmachl, Juergen Ramharter, et al.Nature Chemical Biology|July 10, 2019
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3Jark Böttcher, David Dilworth, Ulrich Reiser, et al.Pageof 2