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Science Translational Medicine|March 22, 2022
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in miceAlexandra Schäfer, David R Martinez, John J Won, et al.Nature Medicine|September 11, 2019
A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse modelStephen R Yant, Andrew Mulato, Derek Hansen, et al.Scientific Reports|February 23, 2023
Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitroSheli R Radoshitzky, Patrick Iversen, Xianghan Lu, et al.Biorxiv : the Preprint Server for Biology|June 9, 2020
Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in miceAndrea J Pruijssers, Amelia S George, Alexandra Schäfer, et al.Journal of Medicinal Chemistry|January 27, 2017
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging VirusesDustin Siegel, Hon C Hui, Edward Doerffler, et al.Cell Reports|July 16, 2020
Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in MiceAndrea J Pruijssers, Amelia S George, Alexandra Schäfer, et al.Biorxiv : the Preprint Server for Biology|July 10, 2023
Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potentialDavid R Martinez, Fernando R Moreira, Mark R Zweigart, et al.Journal of Medicinal Chemistry|August 19, 2023
Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green MonkeysRichard L Mackman, Rao V Kalla, Darius Babusis, et al.Viruses|December 23, 2023
Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment TestingElizabeth E Zumbrun, Carly B Garvey, Jay B Wells, et al.Science Translational Medicine|May 22, 2024
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronavirusesDavid R Martinez, Fernando R Moreira, Nicholas J Catanzaro, et al.Pageof 14