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Archives of Toxicology|May 14, 2014
U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cellsTomas Smutny, Michal Bitman, Michal Urban, et al.
Pharmacological Reports : PR|January 9, 2014
Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytesAlice Rulcova, Lucie Krausova, Tomas Smutny, et al.
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association|September 10, 2017
Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulationJan Dusek, Alejandro Carazo, Frantisek Trejtnar, et al.
EJNMMI Radiopharmacy and Chemistry|April 18, 2024
Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell modelAnna Durinova, Lucie Smutna, Pavel Barta, et al.
British Journal of Pharmacology|February 28, 2016
The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivatorLucie Hyrsova, Tomas Smutny, Alejandro Carazo, et al.
Acta Pharmaceutica Sinica. B|January 31, 2020
The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoidsTomas Smutny, Jan Dusek, Lucie Hyrsova, et al.
Frontiers in Pharmacology|October 27, 2018
Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) SignalingAlejandro Carazo, Jan Dusek, Ondrej Holas, et al.
Toxicology Letters|June 7, 2019
Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liverJan Dusek, Josef Skoda, Ondrej Holas, et al.
Toxicology Letters|November 6, 2018
Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptorsLucie Hyrsova, Alena Vanduchova, Jan Dusek, et al.
Cells|December 1, 2020
Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding DomainJosef Skoda, Jan Dusek, Martin Drastik, et al.
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