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Journal of Medicinal Chemistry|May 5, 2016
2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) AgonistsTomas Smutny, Alice Nova, Marcela Drechslerová, et al.
Molecular Pharmacology|March 1, 2025
LIM and SH3 protein 2 (Lasp2) is a novel pregnane X receptor target gene in mouse liverAnja Konzack, Mikko Karpale, Tomas Smutny, et al.
Molecular Nutrition & Food Research|February 20, 2022
Gene Expression Profiling of 1α,25(OH)2 D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing GenesPetr Pavek, Jan Dusek, Tomas Smutny, et al.
The Journal of Steroid Biochemistry and Molecular Biology|June 8, 2020
3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolismAlzbeta Stefela, Miroslav Kaspar, Martin Drastik, et al.
Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids|September 11, 2017
Iron depletion induces hepatic secretion of biliary lipids and glutathione in ratsAlena Prasnicka, Jolana Cermanova, Milos Hroch, et al.
Journal of Medicinal Chemistry|February 9, 2023
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine StructureIvana Mejdrová, Jan Dušek, Kryštof Škach, et al.
Clinical Pharmacology and Therapeutics|April 23, 2020
Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human HepatocytesDelilah F G Hendriks, Sabine U Vorrink, Tomas Smutny, et al.
Journal of Medicinal Chemistry|July 12, 2025
Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene RegulationRajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, et al.
Nature Communications|February 6, 2025
The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia modelJan Dusek, Ivana Mejdrová, Klára Dohnalová, et al.
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