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Journal of Medicinal Chemistry|July 4, 2018
Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug DesignHuimin Cheng, Brian M Linhares, Wenbo Yu, et al.Nature Structural Biology|April 15, 2003
The DCX-domain tandems of doublecortin and doublecortin-like kinaseMyung Hee Kim, Tomasz Cierpicki, Urszula Derewenda, et al.Science Advances|June 17, 2021
Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancerChunhua Wan, Sylvia Mahara, Claire Sun, et al.Journal of Medicinal Chemistry|January 9, 2016
Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)Dmitry Borkin, Jonathan Pollock, Katarzyna Kempinska, et al.Cancer Cell|June 15, 2007
Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activityYizhou Liu, Wei Chen, Justin Gaudet, et al.Journal of Medicinal Chemistry|May 9, 2018
Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia InteractionDmitry Borkin, Szymon Klossowski, Jonathan Pollock, et al.Protein Science : a Publication of the Protein Society|August 12, 2009
The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoATomasz Cierpicki, Jakub Bielnicki, Meiying Zheng, et al.Journal of Medicinal Chemistry|January 30, 2014
High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interactionShihan He, Timothy J Senter, Jonathan Pollock, et al.Cell Chemical Biology|July 21, 2021
Development of potent dimeric inhibitors of GAS41 YEATS domainDymytrii Listunov, Brian M Linhares, EunGi Kim, et al.The Journal of Clinical Investigation|April 14, 2015
Ash1l controls quiescence and self-renewal potential in hematopoietic stem cellsMorgan Jones, Jennifer Chase, Michelle Brinkmeier, et al.Pageof 10