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Bioorganic & Medicinal Chemistry|August 18, 2012
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubilityTomohiro Ohashi, Yuya Oguro, Toshio Tanaka, et al.Bioorganic & Medicinal Chemistry|August 14, 2012
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivativesMasaaki Hirose, Masanori Okaniwa, Tohru Miyazaki, et al.Journal of Medicinal Chemistry|March 2, 2012
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffoldsMasanori Okaniwa, Masaaki Hirose, Takashi Imada, et al.Journal of Medicinal Chemistry|February 21, 2022
Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel PharmacophoreYuta Tanaka, Masaki Seto, Keiko Kakegawa, et al.Nature Communications|February 25, 2017
CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitorTyler Funnell, Shinya Tasaki, Arusha Oloumi, et al.Pageof 2