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Bioorganic & Medicinal Chemistry Letters|June 10, 2008
Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitorsTony Siu, Jun Liang, Jeannie Arruda, et al.ACS Medicinal Chemistry Letters|June 25, 2025
New Multiparameter Index Is a Strong Predictor of Oral Bioavailability for Heterobifunctional DegradersJavier L Baylon, Matthew J Chalkley, Tony Siu, et al.Nucleic Acids Research|July 24, 2023
Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonismJustyna Sikorska, Yan Hou, Paul Chiurazzi, et al.Bioorganic & Medicinal Chemistry Letters|June 14, 2008
The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activityTony Siu, Yiwei Li, Johnny Nagasawa, et al.Bioorganic & Medicinal Chemistry Letters|December 23, 2008
Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activityYiwei Li, Jun Liang, Tony Siu, et al.Bioorganic & Medicinal Chemistry Letters|March 4, 2014
The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimizationTony Siu, Sathyajith E Kumarasinghe, Michael D Altman, et al.Bioorganic & Medicinal Chemistry Letters|November 4, 2010
The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: hit to leadTony Siu, Ekaterina S Kozina, Joon Jung, et al.ACS Medicinal Chemistry Letters|January 19, 2019
Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STINGTony Siu, Michael D Altman, Gretchen A Baltus, et al.Bioorganic & Medicinal Chemistry Letters|March 2, 2016
Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitorsVladimir Simov, Sujal V Deshmukh, Christopher J Dinsmore, et al.Journal of Medicinal Chemistry|November 21, 2017
The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic PropertiesTony Siu, Jason Brubaker, Peter Fuller, et al.Pageof 2