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Journal of Medicinal Chemistry|May 12, 2012
Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK₁/NK₃ antagonistsCaterina Bissantz, Claudia Bohnert, Torsten Hoffmann, et al.
Journal of Medicinal Chemistry|September 7, 2022
Magnet for the Needle in Haystack: "Crystal Structure First" Fragment Hits Unlock Active Chemical Matter Using Targeted Exploration of Vast Chemical SpacesJanis Müller, Raphael Klein, Olga Tarkhanova, et al.
Bioscience Reports|July 26, 2017
N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activityAstrid Kehlen, Monique Haegele, Livia Böhme, et al.
Biochemistry|August 28, 2002
Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activityStephan Schilling, Torsten Hoffmann, Fred Rosche, et al.
Analytical Biochemistry|March 22, 2002
Continuous spectrometric assays for glutaminyl cyclase activityStephan Schilling, Torsten Hoffmann, Michael Wermann, et al.
Bioorganic & Medicinal Chemistry Letters|November 22, 2017
New Caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment spaceAnne Brethon, Laurent Chantalat, Olivier Christin, et al.
European Journal of Medicinal Chemistry|July 3, 2019
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitorsNikolay T Tzvetkov, Hans-Georg Stammler, Maya G Georgieva, et al.
Biological Chemistry|January 15, 2004
Substrate specificity of glutaminyl cyclases from plants and animalsStephan Schilling, Susanne Manhart, Torsten Hoffmann, et al.
Biological Chemistry|June 11, 2011
Isolation of dipeptidyl peptidase IV (DP 4) isoforms from porcine kidney by preparative isoelectric focusing to improve crystallizationLeona Wagner, Michael Wermann, Fred Rosche, et al.
Biological Chemistry|July 17, 2004
Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient miceJens Rüter, Torsten Hoffmann, Hans-Ulrich Demuth, et al.
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