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International Journal of Clinical Pharmacology and Therapeutics|March 28, 2022
Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract: Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-upToshiaki Tsuchitani, Takeshi Akiyoshi, Ayuko Imaoka, et al.
CPT: Pharmacometrics & Systems Pharmacology|December 3, 2025
Characterizing Apixaban Pharmacokinetics Through Physiologically-Based Pharmacokinetic Modeling: Critical Role of Biliary Secretion and Enterohepatic Circulation in HumansToshiaki Tsuchitani, Wen Kou, Masatoshi Tomi, et al.
Journal of Pharmaceutical Health Care and Sciences|July 1, 2021
Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damageToshiaki Tsuchitani, Takeshi Akiyoshi, Ayuko Imaoka, et al.
Clinical and Translational Science|November 27, 2024
Trends of in vitro pharmacological potency and in vivo pharmacokinetics parameters of modern drugs: Can the therapeutic/subtherapeutic dose be estimated from in vitro K<sub>i</sub> and pharmacokinetic parameters?Toshiaki Tsuchitani, Motohiro Kato, Atsuko Tomaru, et al.
AAPS Pharmscitech|February 10, 2026
Analysis of the Correlation Between Membrane Permeability in RPMI 2650 Cells and Human Nasal AbsorptionTokio Morita, Toshiaki Tsuchitani, Hiroyuki Yoshida, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|June 22, 2026
Mechanistic insights into edoxaban's nonlinear pharmacokinetics and quinidine interaction via P-glycoprotein using physiologically based pharmacokinetic modelingWen Kou, Toshiaki Tsuchitani, Kazuya Maeda, et al.
International Journal of Clinical Pharmacology and Therapeutics|November 16, 2020
Relative contributions of metabolic enzymes to systemic elimination can be estimated from clinical DDI studies: Validation using an in silico approachKana Koinuma, Toshiaki Tsuchitani, Ayuko Imaoka, et al.
CPT: Pharmacometrics & Systems Pharmacology|May 15, 2024
Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target-mediated drug disposition and OATP1B3-mediated hepatic uptake in a physiologically based modelToshiaki Tsuchitani, Atsuko Tomaru, Yasunori Aoki, et al.
Biological & Pharmaceutical Bulletin|December 3, 2023
The Effects of Jabara Juice on the Intestinal Permeation of FexofenadineHongye Han, Takeshi Akiyoshi, Tokio Morita, et al.
The Journal of Physiology|April 24, 2026
MCT1-mediated bidirectional propionate transport across human placental syncytiotrophoblast layer: insights from a trophoblast stem cell-derived barrier modelToshiaki Tsuchitani, Rin Midorikawa, Akari Kasuya, et al.
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