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Journal of Pharmaceutical Sciences|August 29, 2007
Prediction of drug tissue to plasma concentration ratios using a measured volume of distribution in combination with lipophilicityRasmus Jansson, Ulf Bredberg, Michael Ashton
Molecular Pharmaceutics|February 23, 2012
The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transportErik Sjögren, Ulf Bredberg, Hans Lennernäs
Current Topics in Medicinal Chemistry|February 10, 2009
Methodologies to assess brain drug delivery in lead optimizationMargareta Hammarlund-Udenaes, Ulf Bredberg, Markus Fridén
Clinical Pharmacokinetics|June 10, 2003
Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challengesCollen M Masimirembwa, Ulf Bredberg, Tommy B Andersson
Drug Metabolism and Disposition: the Biological Fate of Chemicals|June 27, 2007
In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluidsMarkus Fridén, Anubha Gupta, Madeleine Antonsson, et al.
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism|September 17, 2009
Improved measurement of drug exposure in the brain using drug-specific correction for residual bloodMarkus Fridén, Helena Ljungqvist, Brian Middleton, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|October 1, 2008
The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulationsErik Sjögren, Hans Lennernäs, Tommy B Andersson, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|February 4, 2011
Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environmentErik Sjögren, Joakim Nyberg, Mats O Magnusson, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|March 21, 2009
Development of a high-throughput brain slice method for studying drug distribution in the central nervous systemMarkus Fridén, Frederic Ducrozet, Brian Middleton, et al.
Drug Discovery Today|January 24, 2009
Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerationsJohan Gabrielsson, Hugues Dolgos, Per-Göran Gillberg, et al.
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