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EMBO Reports|October 23, 2023
Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy modelsNagendran Ramalingam, Lisa Brontesi, Shan-Xue Jin, et al.Proceedings of the National Academy of Sciences of the United States of America|July 9, 2015
KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicityUlf Dettmer, Andrew J Newman, Victoria E von Saucken, et al.Biochemistry|December 10, 2014
Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purityEric S Luth, Tim Bartels, Ulf Dettmer, et al.Metabolic Brain Disease|January 24, 2025
Acute lipid droplet accumulation induced by the inhibition of the phospholipase DDHD2 does not affect the level, solubility, or phosphoserine-129 status of α-synucleinMagdalena M Bolsinger, Tim E Moors, Lisa Brontesi, et al.Movement Disorders : Official Journal of the Movement Disorder Society|October 26, 2020
Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and NeurotoxicityGary P H Ho, Nagendran Ramalingam, Thibaut Imberdis, et al.Brain Research|February 11, 2021
Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced α-synuclein membrane interactionMaria Ericsson, Victoria von Saucken, Andrew J Newman, et al.FEBS Letters|November 21, 2023
Adding hydrophobicity or positive charges to the cytosolic half of the α-synuclein 3-11 helix increases membrane association and S129 phosphorylationKazuma Shimanaka, Bryan Shi, Lisa Brontesi, et al.The Journal of Biological Chemistry|June 12, 2010
Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complexUlf Dettmer, Peer-Hendrik Kuhn, Claudia Abou-Ajram, et al.Bioorganic & Medicinal Chemistry|February 8, 2024
Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrilsAhmed A Elbatrawy, Taiwo A Ademoye, Heba Alnakhala, et al.Human Molecular Genetics|July 13, 2021
Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicityTae-Eun Kim, Andrew J Newman, Thibaut Imberdis, et al.Pageof 8