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Frontiers in Bioengineering and Biotechnology|February 23, 2023
In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twinJules Dichamp, Geraldine Cellière, Ahmed Ghallab, et al.
Archives of Toxicology|June 1, 2017
Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertilityChristiane Rennert, Franziska Eplinius, Ute Hofmann, et al.
Plos One|September 28, 2011
Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysisMichael A Dengler, Annette M Staiger, Matthias Gutekunst, et al.
Genome Medicine|November 10, 2016
Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transportersJohannes Matthaei, Mladen V Tzvetkov, Valerie Gal, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|August 28, 2015
Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor AgonistsAlbert Braeuning, Maria Thomas, Ute Hofmann, et al.
Scientific Reports|July 26, 2017
Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damageArne Schenk, Ahmed Ghallab, Ute Hofmann, et al.
Genome Medicine|December 27, 2011
DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinomaElke Schaeffeler, Claus Hellerbrand, Anne T Nies, et al.
International Journal of Molecular Sciences|January 5, 2021
Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver CellsLisa Goedtke, Heike Sprenger, Ute Hofmann, et al.
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology|February 27, 2008
Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study GroupMatthias Schwab, Ulrich M Zanger, Claudia Marx, et al.
Cell Death Discovery|April 21, 2022
The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXASandra Weller, Astrid Toennießen, Benjamin Schaefer, et al.
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