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V J Chen

Showing results (11-20 of 23) with videos related to

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Seminars in Oncology|December 22, 1999
Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesisL G Mendelsohn, C Shih, V J Chen, et al.
Seminars in Oncology|December 22, 1999
Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugsR M Schultz, V J Chen, J R Bewley, et al.
Biochemistry|May 19, 1992
Thiolate ligation of the active site Fe2+ of isopenicillin N synthase derives from substrate rather than endogenous cysteine: spectroscopic studies of site-specific Cys----Ser mutated enzymesA M Orville, V J Chen, A Kriauciunas, et al.
Current Genetics|December 1, 1990
Gene disruption of the pcbAB gene encoding ACV synthetase in Cephalosporium acremoniumJ A Hoskins, N O'Callaghan, S W Queener, et al.
The Journal of Biological Chemistry|December 25, 1989
Spectroscopic studies of isopenicillin N synthase. A mononuclear nonheme Fe2+ oxidase with metal coordination sites for small molecules and substrateV J Chen, A M Orville, M R Harpel, et al.
The Journal of Biological Chemistry|June 25, 1991
The functional role of cysteines in isopenicillin N synthase. Correlation of cysteine reactivities toward sulfhydryl reagents with kinetic properties of cysteine mutantsA Kriauciunas, C A Frolik, T C Hassell, et al.
Journal of Bacteriology|September 1, 1988
Cloning and expression in Escherichia coli of isopenicillin N synthetase genes from Streptomyces lipmanii and Aspergillus nidulansB J Weigel, S G Burgett, V J Chen, et al.
Biochemistry|June 1, 2000
Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolaseA Schmidt, H Wu, R E MacKenzie, et al.
The Journal of Pharmacology and Experimental Therapeutics|October 9, 1998
The antiproliferative and cell cycle effects of 5,6,7, 8-tetrahydro-N5,N10-carbonylfolic acid, an inhibitor of methylenetetrahydrofolate dehydrogenase, are potentiated by hypoxanthineJ L Tonkinson, L L Habeck, J E Toth, et al.
British Journal of Cancer|August 26, 1998
Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cellsV J Chen, J R Bewley, S L Andis, et al.
Pageof 3

Showing results (11-20 of 23) with videos related to

Sort By:
Pageof 3
Seminars in Oncology|December 22, 1999
Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesisL G Mendelsohn, C Shih, V J Chen, et al.
Seminars in Oncology|December 22, 1999
Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugsR M Schultz, V J Chen, J R Bewley, et al.
Biochemistry|May 19, 1992
Thiolate ligation of the active site Fe2+ of isopenicillin N synthase derives from substrate rather than endogenous cysteine: spectroscopic studies of site-specific Cys----Ser mutated enzymesA M Orville, V J Chen, A Kriauciunas, et al.
Current Genetics|December 1, 1990
Gene disruption of the pcbAB gene encoding ACV synthetase in Cephalosporium acremoniumJ A Hoskins, N O'Callaghan, S W Queener, et al.
The Journal of Biological Chemistry|December 25, 1989
Spectroscopic studies of isopenicillin N synthase. A mononuclear nonheme Fe2+ oxidase with metal coordination sites for small molecules and substrateV J Chen, A M Orville, M R Harpel, et al.
The Journal of Biological Chemistry|June 25, 1991
The functional role of cysteines in isopenicillin N synthase. Correlation of cysteine reactivities toward sulfhydryl reagents with kinetic properties of cysteine mutantsA Kriauciunas, C A Frolik, T C Hassell, et al.
Journal of Bacteriology|September 1, 1988
Cloning and expression in Escherichia coli of isopenicillin N synthetase genes from Streptomyces lipmanii and Aspergillus nidulansB J Weigel, S G Burgett, V J Chen, et al.
Biochemistry|June 1, 2000
Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolaseA Schmidt, H Wu, R E MacKenzie, et al.
The Journal of Pharmacology and Experimental Therapeutics|October 9, 1998
The antiproliferative and cell cycle effects of 5,6,7, 8-tetrahydro-N5,N10-carbonylfolic acid, an inhibitor of methylenetetrahydrofolate dehydrogenase, are potentiated by hypoxanthineJ L Tonkinson, L L Habeck, J E Toth, et al.
British Journal of Cancer|August 26, 1998
Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cellsV J Chen, J R Bewley, S L Andis, et al.
Pageof 3