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Pharmaceutics|July 2, 2021
Surfactant-Assisted Distal Pulmonary Distribution of Budesonide Revealed by Mass Spectrometry ImagingRiccardo Zecchi, Pietro Franceschi, Laura Tigli, et al.
Bioorganic & Medicinal Chemistry Letters|March 23, 2021
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)Fabio Rancati, Ian D Linney, Andrea Rizzi, et al.
Journal of Medicinal Chemistry|June 22, 2024
Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by InhalationPaolo Bruno, Alessandra Micoli, Mauro Corsi, et al.
Respiratory Research|August 7, 2019
Mass spectrometry imaging as a tool for evaluating the pulmonary distribution of exogenous surfactant in premature lambsRiccardo Zecchi, Pietro Franceschi, Laura Tigli, et al.
Journal of Medicinal Chemistry|June 10, 2024
Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory DiseasesLaura Carzaniga, Ian D Linney, Andrea Rizzi, et al.
The Journal of Pharmacology and Experimental Therapeutics|January 11, 2015
CHF6001 II: a novel phosphodiesterase 4 inhibitor, suitable for topical pulmonary administration--in vivo preclinical pharmacology profile defines a potent anti-inflammatory compound with a wide therapeutic windowGino Villetti, Chiara Carnini, Loredana Battipaglia, et al.
Journal of Medicinal Chemistry|July 28, 2022
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory DiseasesLaura Carzaniga, Ian D Linney, Andrea Rizzi, et al.
Journal of Medicinal Chemistry|February 20, 2026
A Journey through Scaffolds: Indolines, Pyrrolidines, and Azetidines in the Quest for Inhaled DDR Inhibitors for IPFLaura Carzaniga, Andrea Rizzi, Roberta Mazzucato, et al.
Journal of Medicinal Chemistry|December 5, 2024
Discovery of CHF-6523, an Inhaled Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary DiseasePaolo Bruno, Daniele Pala, Alessandra Micoli, et al.
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