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Journal of Chemical Information and Modeling|July 9, 2025
Agonists and Antagonists Show Different Unbinding Paths from the TLR8 ReceptorValerij Talagayev, Gerhard Wolber, Ariane Nunes-AlvesDrug Discovery Today|October 9, 2025
Structure-guided approaches to modulate endosomal toll-like receptors TLR7, TLR8 and TLR9: advances, challenges and therapeutic promiseTroy Matziol, Valerij Talagayev, Günther Weindl, et al.Journal of Chemical Information and Modeling|December 10, 2025
Fingerprint-Based Machine Learning for SARS-CoV-2 and MERS-CoV Mpro Inhibition: Highlighting the Potential of Bayesian Neural NetworksNiklas Piet Doering, Valerij Talagayev, Sijie Liu, et al.Biorxiv : the Preprint Server for Biology|August 8, 2025
Small Molecule-Based Blockade of CD28 Suppresses T Cell Costimulation Across Cellular and Mucosal Co-culture ModelsSaurabh Upadhyay, Valerij Talagayev, Sungwoo Cho, et al.European Journal of Medicinal Chemistry|September 24, 2025
Structure-based virtual screening identifies potent CD28 inhibitors that suppress T cell co-stimulation in cellular and mucosal modelsSaurabh Upadhyay, Valerij Talagayev, Sungwoo Cho, et al.Journal of Medicinal Chemistry|August 11, 2023
Discovery of Small-Molecule TIM-3 Inhibitors for Acute Myeloid Leukemia Using Pharmacophore-Based Virtual ScreeningSomaya A Abdel-Rahman, Valerij Talagayev, Szymon Pach, et al.ACS Medicinal Chemistry Letters|November 20, 2024
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3Natalie Fuchs, Laura Calvo-Barreiro, Valerij Talagayev, et al.Chemmedchem|October 16, 2023
Discovery of ICOS-Targeted Small Molecules Using Pharmacophore-Based ScreeningLaura Calvo-Barreiro, Valerij Talagayev, Szymon Pach, et al.Acta Pharmaceutica (Zagreb, Croatia)|April 30, 2025
Optimization of 6-(trifluoromethyl)pyrimidine derivatives as TLR8 antagonistsNika Strašek Benedik, Valerij Talagayev, Troy Matziol, et al.Journal of Medicinal Chemistry|February 14, 2025
Discovery of Novel Isoxazole-Based Small-Molecule Toll-Like Receptor 8 AntagonistsTroy Matziol, Valerij Talagayev, Tjaša Slokan, et al.Pageof 25