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Journal of Medicinal Chemistry|April 2, 2021
Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ ImmunomodulatorsJoey L Methot, Hua Zhou, Meredeth A McGowan, et al.Journal of Medicinal Chemistry|March 21, 2024
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative DiseasesRobert A Craig, Javier De Vicente, Anthony A Estrada, et al.Clinical and Translational Science|June 1, 2022
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patientsMaurits F J M Vissers, Jules A A C Heuberger, Geert Jan Groeneveld, et al.Journal of Medicinal Chemistry|December 5, 2022
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral SclerosisRobert A Craig, Brian M Fox, Cheng Hu, et al.ACS Medicinal Chemistry Letters|July 21, 2015
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical EvaluationShawn P Walsh, Aurash Shahripour, Haifeng Tang, et al.Pageof 3