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ACS Medicinal Chemistry Letters|August 23, 2021
Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate CancerZhuming Zhang, Peter J Connolly, Luis Trabalón Escolar, et al.
ACS Medicinal Chemistry Letters|November 20, 2020
A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding ModeVineet Pande, Weimei Sun, Lijs Beke, et al.
SLAS Discovery : Advancing Life Sciences R & D|May 5, 2022
Identification of Two Non-Peptidergic Small Molecule Inhibitors of CBX2 Binding to K27 Trimethylated OligonucleosomesLukas Lercher, Nina Simon, Andreas Bergmann, et al.
Journal of Medicinal Chemistry|January 20, 2021
Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC)Zhuming Zhang, Peter J Connolly, Heng Keang Lim, et al.
Molecular Cancer Therapeutics|March 2, 2021
Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate CancerJonathan R Branch, Tammy L Bush, Vineet Pande, et al.
Bioorganic & Medicinal Chemistry Letters|August 26, 2018
Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonistsDavid C McGowan, Florence Herschke, Mourad D Khamlichi, et al.
Journal of Medicinal Chemistry|July 3, 2018
2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B VirusWerner Embrechts, Florence Herschke, Frederik Pauwels, et al.
Journal of Computational Chemistry|September 5, 2025
A New Fragment-Based Pharmacophore Virtual Screening Workflow Identifies Potent Inhibitors of SARS-CoV-2 NSP13 HelicaseJordi Doijen, Jiexiong Xie, Simone Marsili, et al.
Journal of Medicinal Chemistry|July 19, 2021
Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal CancerZhuming Zhang, Avijit Ghosh, Peter J Connolly, et al.
Molecular Cancer Therapeutics|September 29, 2021
Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor ActivityDirk Brehmer, Lijs Beke, Tongfei Wu, et al.
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