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Vipulkumar K Patel

Showing results (11-20 of 21) with videos related to

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Angewandte Chemie (International Ed. in English)|August 4, 2020
A Photoaffinity-Based Fragment-Screening Platform for Efficient Identification of Protein LigandsEmma K Grant, David J Fallon, Michael M Hann, et al.
Bioorganic & Medicinal Chemistry Letters|June 30, 2007
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokineticsPaul Bamborough, Richard M Angell, Inder Bhamra, et al.
Drug Discovery Today|September 21, 2013
A practical drug discovery project at the undergraduate levelM Jonathan Fray, Simon J F Macdonald, Ian R Baldwin, et al.
Journal of Medicinal Chemistry|December 10, 2016
Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA<sub>2</sub>)Alison J-A Woolford, Philip J Day, Véronique Bénéton, et al.
Bioorganic & Medicinal Chemistry Letters|May 16, 2006
Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitorsNigel S Watson, David Brown, Matthew Campbell, et al.
Journal of Medicinal Chemistry|September 13, 2021
Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding ModeKenneth Down, Augustin Amour, Niall A Anderson, et al.
Bioorganic & Medicinal Chemistry Letters|September 10, 2011
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitorJohn Liddle, Francis L Atkinson, Michael D Barker, et al.
Journal of Medicinal Chemistry|May 12, 2016
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment ScreeningAlison J-A Woolford, Joseph E Pero, Sridhar Aravapalli, et al.
Journal of Medicinal Chemistry|November 15, 2022
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432Philip G Humphreys, Niall A Anderson, Paul Bamborough, et al.
Journal of Medicinal Chemistry|January 7, 2020
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment ScreeningChristopher R Wellaway, Dominique Amans, Paul Bamborough, et al.
Pageof 3

Showing results (11-20 of 21) with videos related to

Sort By:
Pageof 3
Angewandte Chemie (International Ed. in English)|August 4, 2020
A Photoaffinity-Based Fragment-Screening Platform for Efficient Identification of Protein LigandsEmma K Grant, David J Fallon, Michael M Hann, et al.
Bioorganic & Medicinal Chemistry Letters|June 30, 2007
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokineticsPaul Bamborough, Richard M Angell, Inder Bhamra, et al.
Drug Discovery Today|September 21, 2013
A practical drug discovery project at the undergraduate levelM Jonathan Fray, Simon J F Macdonald, Ian R Baldwin, et al.
Journal of Medicinal Chemistry|December 10, 2016
Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA<sub>2</sub>)Alison J-A Woolford, Philip J Day, Véronique Bénéton, et al.
Bioorganic & Medicinal Chemistry Letters|May 16, 2006
Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitorsNigel S Watson, David Brown, Matthew Campbell, et al.
Journal of Medicinal Chemistry|September 13, 2021
Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding ModeKenneth Down, Augustin Amour, Niall A Anderson, et al.
Bioorganic & Medicinal Chemistry Letters|September 10, 2011
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitorJohn Liddle, Francis L Atkinson, Michael D Barker, et al.
Journal of Medicinal Chemistry|May 12, 2016
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment ScreeningAlison J-A Woolford, Joseph E Pero, Sridhar Aravapalli, et al.
Journal of Medicinal Chemistry|November 15, 2022
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432Philip G Humphreys, Niall A Anderson, Paul Bamborough, et al.
Journal of Medicinal Chemistry|January 7, 2020
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment ScreeningChristopher R Wellaway, Dominique Amans, Paul Bamborough, et al.
Pageof 3