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Cancers|January 26, 2024
Antibody-Drug Conjugates: The Dynamic Evolution from Conventional to Next-Generation ConstructsVirginia Metrangolo, Lars H Engelholm
Cancers|November 13, 2021
The Urokinase Receptor (uPAR) as a "Trojan Horse" in Targeted Cancer Therapy: Challenges and OpportunitiesVirginia Metrangolo, Michael Ploug, Lars H Engelholm
Science Advances|January 17, 2025
Targeting uPAR with an antibody-drug conjugate suppresses tumor growth and reshapes the immune landscape in pancreatic cancer modelsVirginia Metrangolo, Michaela Hansen Blomquist, Ananya Dutta, et al.
Molecular Cancer Therapeutics|July 16, 2025
The recycling collagen receptor uPARAP is a unique mediator of stromal drug delivery to carcinoma cellsKirstine S Nørregaard, Ida M E Larsen, Henrik J Jürgensen, et al.
Cell|May 14, 2026
Navigating the clinical progress of antibody-drug conjugates: Emerging opportunities and remaining challengesLouise Conilh, Virginia Metrangolo, Silvia Crescioli, et al.
The Journal of Biological Chemistry|May 20, 2020
The collagen receptor uPARAP/Endo180 regulates collectins through unique structural elements in its FNII domainKirstine Sandal Nørregaard, Oliver Krigslund, Niels Behrendt, et al.
International Journal of Oncology|August 29, 2015
The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)Maria C Melander, Henrik J Jürgensen, Daniel H Madsen, et al.
International Journal of Cancer|March 29, 2002
Urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cellsBoye Schnack Nielsen, Fritz Rank, Lars H Engelholm, et al.
Experimental Cell Research|January 20, 2004
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IVLars Kjøller, Lars H Engelholm, Maria Høyer-Hansen, et al.
Biological Chemistry|July 17, 2008
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cellsSigne Ingvarsen, Daniel H Madsen, Thore Hillig, et al.
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