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Applied and Environmental Microbiology|March 10, 2015
Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 ReductaseClaire L Price, Andrew G S Warrilow, Josie E Parker, et al.
The Journal of Biological Chemistry|October 18, 2018
Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51Tatiana Y Hargrove, Zdzislaw Wawrzak, Paxtyn M Fisher, et al.
Antimicrobial Agents and Chemotherapy|July 14, 2010
Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51)Andrew G S Warrilow, Claire M Martel, Josie E Parker, et al.
Plos Neglected Tropical Diseases|December 29, 2017
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)Anjan Debnath, Claudia M Calvet, Gareth Jennings, et al.
Antimicrobial Agents and Chemotherapy|May 28, 2015
Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)David C Lamb, Andrew G S Warrilow, Nicola J Rolley, et al.
Applied and Environmental Microbiology|August 3, 2014
Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51)Andrew G S Warrilow, Claire M Hull, Nicola J Rolley, et al.
Chemistry & Biology|November 21, 2007
Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growthGalina I Lepesheva, Robert D Ott, Tatiana Y Hargrove, et al.
Phytochemistry|August 19, 2014
Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineageBrad A Haubrich, Emily K Collins, Alicia L Howard, et al.
Antimicrobial Agents and Chemotherapy|May 11, 2016
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human EnzymeAndrew G S Warrilow, Josie E Parker, Claire L Price, et al.
Journal of Medicinal Chemistry|June 13, 2018
Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic AnalysisLaura Friggeri, Tatiana Y Hargrove, Zdzislaw Wawrzak, et al.
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