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The Journal of Pharmacology and Experimental Therapeutics
|
November 18, 2011
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease
Carrie K Jones, Michael Bubser, Analisa D Thompson, et al.
JACC. Basic to Translational Science
|
December 14, 2023
Development of a Peripherally Restricted 5-HT<sub>2B</sub> Partial Agonist for Treatment of Pulmonary Arterial Hypertension
Michael S Valentine, Aaron M Bender, Sheila Shay, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|
June 26, 2015
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model
A Ghoshal, J M Rook, J W Dickerson, et al.
ACS Chemical Neuroscience
|
April 28, 2018
A Novel M<sub>1</sub> PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity
Jerri M Rook, Jeanette L Bertron, Hyekyung P Cho, et al.
ACS Chemical Neuroscience
|
December 22, 2016
Diverse Effects on M<sub>1</sub> Signaling and Adverse Effect Liability within a Series of M<sub>1</sub> Ago-PAMs
Jerri M Rook, Masahito Abe, Hyekyung P Cho, et al.
ACS Medicinal Chemistry Letters
|
August 20, 2021
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M<sub>4</sub> Muscarinic Acetylcholine Receptor Antagonist
Matthew Spock, Trever R Carter, Katrina A Bollinger, et al.
ACS Chemical Neuroscience
|
August 28, 2024
Discovery of VU6007496: Challenges in the Development of an M<sub>1</sub> Positive Allosteric Modulator Backup Candidate
Julie L Engers, Katrina A Bollinger, Rory A Capstick, et al.
ACS Chemical Neuroscience
|
March 25, 2025
Application of Deuterium in an M<sub>1</sub> Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422
Julie L Engers, Jinming Li, Changho Han, et al.
ACS Chemical Neuroscience
|
February 5, 2025
Further Optimization of the mGlu<sub>1</sub> PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
ACS Chemical Neuroscience
|
November 26, 2025
Discovery of VU6052254: A Novel, Potent M<sub>1</sub> Positive Allosteric Modulator
Julie L Engers, Joseph D Bungard, Christopher C Presley, et al.
Page
of 30
Search research articles
Search
Showing results (281-290 of 300) with videos related to
Sort By:
Page
of 30
The Journal of Pharmacology and Experimental Therapeutics
|
November 18, 2011
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease
Carrie K Jones, Michael Bubser, Analisa D Thompson, et al.
JACC. Basic to Translational Science
|
December 14, 2023
Development of a Peripherally Restricted 5-HT<sub>2B</sub> Partial Agonist for Treatment of Pulmonary Arterial Hypertension
Michael S Valentine, Aaron M Bender, Sheila Shay, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|
June 26, 2015
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model
A Ghoshal, J M Rook, J W Dickerson, et al.
ACS Chemical Neuroscience
|
April 28, 2018
A Novel M<sub>1</sub> PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity
Jerri M Rook, Jeanette L Bertron, Hyekyung P Cho, et al.
ACS Chemical Neuroscience
|
December 22, 2016
Diverse Effects on M<sub>1</sub> Signaling and Adverse Effect Liability within a Series of M<sub>1</sub> Ago-PAMs
Jerri M Rook, Masahito Abe, Hyekyung P Cho, et al.
ACS Medicinal Chemistry Letters
|
August 20, 2021
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M<sub>4</sub> Muscarinic Acetylcholine Receptor Antagonist
Matthew Spock, Trever R Carter, Katrina A Bollinger, et al.
ACS Chemical Neuroscience
|
August 28, 2024
Discovery of VU6007496: Challenges in the Development of an M<sub>1</sub> Positive Allosteric Modulator Backup Candidate
Julie L Engers, Katrina A Bollinger, Rory A Capstick, et al.
ACS Chemical Neuroscience
|
March 25, 2025
Application of Deuterium in an M<sub>1</sub> Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422
Julie L Engers, Jinming Li, Changho Han, et al.
ACS Chemical Neuroscience
|
February 5, 2025
Further Optimization of the mGlu<sub>1</sub> PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
ACS Chemical Neuroscience
|
November 26, 2025
Discovery of VU6052254: A Novel, Potent M<sub>1</sub> Positive Allosteric Modulator
Julie L Engers, Joseph D Bungard, Christopher C Presley, et al.
Page
of 30