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The Journal of Biological Chemistry|October 5, 2019
The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activityTuong-Vi Nguyen, Shihua Yao, Yahong Wang, et al.
Oncotarget|August 9, 2014
Structural basis of nSH2 regulation and lipid binding in PI3KαMichelle S Miller, Oleg Schmidt-Kittler, David M Bolduc, et al.
Biochemistry|July 5, 2023
Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening AssayMackenzie J Parker, Hyelee Lee, Shihua Yao, et al.
ACS Medicinal Chemistry Letters|January 25, 2021
Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3Ryan A Brawn, Andrew Cook, Kiyoyuki Omoto, et al.
Cell Chemical Biology|February 5, 2020
Small Molecule Inhibition of CPS1 Activity through an Allosteric PocketShihua Yao, Tuong-Vi Nguyen, Alan Rolfe, et al.
American Journal of Human Genetics|February 22, 2023
Development of an oral treatment that rescues gait ataxia and retinal degeneration in a phenotypic mouse model of familial dysautonomiaElisabetta Morini, Anil Chekuri, Emily M Logan, et al.
Molecular Cancer Therapeutics|June 1, 2022
Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast CancerCraig Furman, Xiaoling Puyang, Zhaojie Zhang, et al.
Cancer Discovery|July 12, 2018
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast CancerXiaoling Puyang, Craig Furman, Guo Zhu Zheng, et al.
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