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W Lindsley

Showing results (311-320 of 570) with videos related to

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Journal of Medicinal Chemistry|May 15, 2009
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatinsThomas M Bridges, Joy E Marlo, Colleen M Niswender, et al.
Frontiers in Immunology|May 20, 2024
KMT2D regulates activation, localization, and integrin expression by T-cellsSarah J Potter, Li Zhang, Michael Kotliar, et al.
Bioorganic & Medicinal Chemistry Letters|April 16, 2016
Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonistsJonathan O Witt, Andrea L McCollum, Miguel A Hurtado, et al.
The Journal of Biological Chemistry|September 5, 2022
Differential activity of mGlu<sub>7</sub> allosteric modulators provides evidence for mGlu<sub>7/8</sub> heterodimers at hippocampal Schaffer collateral-CA1 synapsesXin Lin, Nicole M Fisher, Shalini Dogra, et al.
ACS Bio & Med Chem Au|April 27, 2023
Discovery of "Molecular Switches" within a Series of mGlu<sub>5</sub> Allosteric Ligands Driven by a "Magic Methyl" Effect Affording Both PAMs and NAMs with <i>In Vivo</i> Activity, Derived from an M<sub>1</sub> PAM ChemotypeLisa Barbaro, Alice L Rodriguez, Ashlyn N Blevins, et al.
ACS Chemical Biology|November 11, 2014
Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymesSarah A Scott, Cierra T Spencer, Matthew C O'Reilly, et al.
Oncogene|August 6, 2013
Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83BR Cipriano, B L Bryson, K L S Miskimen, et al.
Bioorganic & Medicinal Chemistry Letters|March 27, 2019
Surveying heterocycles as amide bioisosteres within a series of mGlu<sub>7</sub> NAMs: Discovery of VU6019278Carson W Reed, Jordan P Washecheck, Marc C Quitlag, et al.
Journal of Medicinal Chemistry|October 2, 2015
Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in SchizophrenicsPedro M Garcia-Barrantes, Hyekyung P Cho, Colleen M Niswender, et al.
Sleep|December 12, 2018
Direct activation of G-protein-gated inward rectifying K+ channels promotes nonrapid eye movement sleepBende Zou, William S Cao, Zhiwei Guan, et al.
Pageof 57

Showing results (311-320 of 570) with videos related to

Sort By:
Pageof 57
Journal of Medicinal Chemistry|May 15, 2009
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatinsThomas M Bridges, Joy E Marlo, Colleen M Niswender, et al.
Frontiers in Immunology|May 20, 2024
KMT2D regulates activation, localization, and integrin expression by T-cellsSarah J Potter, Li Zhang, Michael Kotliar, et al.
Bioorganic & Medicinal Chemistry Letters|April 16, 2016
Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonistsJonathan O Witt, Andrea L McCollum, Miguel A Hurtado, et al.
The Journal of Biological Chemistry|September 5, 2022
Differential activity of mGlu<sub>7</sub> allosteric modulators provides evidence for mGlu<sub>7/8</sub> heterodimers at hippocampal Schaffer collateral-CA1 synapsesXin Lin, Nicole M Fisher, Shalini Dogra, et al.
ACS Bio & Med Chem Au|April 27, 2023
Discovery of "Molecular Switches" within a Series of mGlu<sub>5</sub> Allosteric Ligands Driven by a "Magic Methyl" Effect Affording Both PAMs and NAMs with <i>In Vivo</i> Activity, Derived from an M<sub>1</sub> PAM ChemotypeLisa Barbaro, Alice L Rodriguez, Ashlyn N Blevins, et al.
ACS Chemical Biology|November 11, 2014
Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymesSarah A Scott, Cierra T Spencer, Matthew C O'Reilly, et al.
Oncogene|August 6, 2013
Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83BR Cipriano, B L Bryson, K L S Miskimen, et al.
Bioorganic & Medicinal Chemistry Letters|March 27, 2019
Surveying heterocycles as amide bioisosteres within a series of mGlu<sub>7</sub> NAMs: Discovery of VU6019278Carson W Reed, Jordan P Washecheck, Marc C Quitlag, et al.
Journal of Medicinal Chemistry|October 2, 2015
Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in SchizophrenicsPedro M Garcia-Barrantes, Hyekyung P Cho, Colleen M Niswender, et al.
Sleep|December 12, 2018
Direct activation of G-protein-gated inward rectifying K+ channels promotes nonrapid eye movement sleepBende Zou, William S Cao, Zhiwei Guan, et al.
Pageof 57