Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Filters

W Lindsley

Showing results (391-400 of 570) with videos related to

Pageof 57
Sort By:
Bioorganic & Medicinal Chemistry Letters|October 18, 2017
Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotype via scaffold hoppingMadeline F Long, Julie L Engers, Sichen Chang, et al.
Journal of Biomolecular Screening|April 17, 2015
Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)Emery Smith, Peter Chase, Colleen M Niswender, et al.
Bioorganic & Medicinal Chemistry Letters|October 2, 2013
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit bindingMark Turlington, Aspen Chun, Sakshi Tomar, et al.
JCI Insight|January 21, 2021
A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypesNicole M Fisher, Aqeela AlHashim, Aditi B Buch, et al.
ACS Chemical Neuroscience|February 21, 2025
Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator <i>In Vivo</i> Tool CompoundKentaro Yashiro, Yuzo Iwaki, Hirohito Urata, et al.
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology|August 24, 2023
Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma (NAVIGATOR)Ian D Pavord, Flavia C L Hoyte, Andrew W Lindsley, et al.
Bioorganic & Medicinal Chemistry Letters|July 4, 2012
Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012Bruce J Melancon, Thomas J Utley, Christian Sevel, et al.
Bioorganic & Medicinal Chemistry Letters|December 4, 2012
Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonismDouglas J Sheffler, Christian Sevel, Uyen Le, et al.
Investigative Ophthalmology & Visual Science|January 26, 2018
Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for RetinoblastomaAnthony B Daniels, Michael T Froehler, Janene M Pierce, et al.
Neuron|December 22, 2017
Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M<sub>4</sub> Muscarinic ReceptorMark S Moehle, Tristano Pancani, Nellie Byun, et al.
Pageof 57

Showing results (391-400 of 570) with videos related to

Sort By:
Pageof 57
Bioorganic & Medicinal Chemistry Letters|October 18, 2017
Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotype via scaffold hoppingMadeline F Long, Julie L Engers, Sichen Chang, et al.
Journal of Biomolecular Screening|April 17, 2015
Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)Emery Smith, Peter Chase, Colleen M Niswender, et al.
Bioorganic & Medicinal Chemistry Letters|October 2, 2013
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit bindingMark Turlington, Aspen Chun, Sakshi Tomar, et al.
JCI Insight|January 21, 2021
A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypesNicole M Fisher, Aqeela AlHashim, Aditi B Buch, et al.
ACS Chemical Neuroscience|February 21, 2025
Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator <i>In Vivo</i> Tool CompoundKentaro Yashiro, Yuzo Iwaki, Hirohito Urata, et al.
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology|August 24, 2023
Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma (NAVIGATOR)Ian D Pavord, Flavia C L Hoyte, Andrew W Lindsley, et al.
Bioorganic & Medicinal Chemistry Letters|July 4, 2012
Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012Bruce J Melancon, Thomas J Utley, Christian Sevel, et al.
Bioorganic & Medicinal Chemistry Letters|December 4, 2012
Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonismDouglas J Sheffler, Christian Sevel, Uyen Le, et al.
Investigative Ophthalmology & Visual Science|January 26, 2018
Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for RetinoblastomaAnthony B Daniels, Michael T Froehler, Janene M Pierce, et al.
Neuron|December 22, 2017
Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M<sub>4</sub> Muscarinic ReceptorMark S Moehle, Tristano Pancani, Nellie Byun, et al.
Pageof 57