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W Lindsley

Showing results (401-410 of 570) with videos related to

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Bioorganic & Medicinal Chemistry Letters|January 31, 2009
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitorsZhijian Zhao, William H Leister, Julie A O'Brien, et al.
Journal of Medicinal Chemistry|August 23, 2014
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
International Forum of Allergy & Rhinology|January 6, 2026
Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)Joaquim Mullol, Joseph K Han, Tanya M Laidlaw, et al.
Bioorganic & Medicinal Chemistry Letters|January 4, 2011
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probePaul R Reid, Thomas M Bridges, Douglas J Sheffler, et al.
Journal of Medicinal Chemistry|January 21, 2011
Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in ratsDarren W Engers, Julie R Field, Uyen Le, et al.
The Journal of Pharmacology and Experimental Therapeutics|January 30, 2004
A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrainJulie A O'Brien, Wei Lemaire, Marion Wittmann, et al.
The Journal of Pharmacology and Experimental Therapeutics|September 6, 2008
Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in ratsAshley E Brady, Carrie K Jones, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|December 1, 2019
Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotypeKayla J Temple, Julie L Engers, Madeline F Long, et al.
Neuron|November 22, 2015
M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced DyskinesiaWeixing Shen, Joshua L Plotkin, Veronica Francardo, et al.
Biological Psychiatry|April 26, 2020
Acetylcholine Muscarinic M<sub>4</sub> Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and RodentsLeigh C Walker, Alice E Berizzi, Nicola A Chen, et al.
Pageof 57

Showing results (401-410 of 570) with videos related to

Sort By:
Pageof 57
Bioorganic & Medicinal Chemistry Letters|January 31, 2009
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitorsZhijian Zhao, William H Leister, Julie A O'Brien, et al.
Journal of Medicinal Chemistry|August 23, 2014
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
International Forum of Allergy & Rhinology|January 6, 2026
Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)Joaquim Mullol, Joseph K Han, Tanya M Laidlaw, et al.
Bioorganic & Medicinal Chemistry Letters|January 4, 2011
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probePaul R Reid, Thomas M Bridges, Douglas J Sheffler, et al.
Journal of Medicinal Chemistry|January 21, 2011
Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in ratsDarren W Engers, Julie R Field, Uyen Le, et al.
The Journal of Pharmacology and Experimental Therapeutics|January 30, 2004
A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrainJulie A O'Brien, Wei Lemaire, Marion Wittmann, et al.
The Journal of Pharmacology and Experimental Therapeutics|September 6, 2008
Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in ratsAshley E Brady, Carrie K Jones, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|December 1, 2019
Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotypeKayla J Temple, Julie L Engers, Madeline F Long, et al.
Neuron|November 22, 2015
M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced DyskinesiaWeixing Shen, Joshua L Plotkin, Veronica Francardo, et al.
Biological Psychiatry|April 26, 2020
Acetylcholine Muscarinic M<sub>4</sub> Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and RodentsLeigh C Walker, Alice E Berizzi, Nicola A Chen, et al.
Pageof 57