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ACS Medicinal Chemistry Letters
|
September 28, 2018
VU6007477, a Novel M<sub>1</sub> PAM Based on a Pyrrolo[2,3-<i>b</i>]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events
Julie L Engers, Elizabeth S Childress, Madeline F Long, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|
March 28, 2018
M<sub>1</sub>-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition
Sean P Moran, Jonathan W Dickerson, Hyekyung P Cho, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
October 2, 2014
Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration
Daisuke Tsugawa, Yuki Oya, Ryota Masuzaki, et al.
Journal of Medicinal Chemistry
|
November 26, 2014
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)
Lindsey C Morris, Kellie D Nance, Patrick R Gentry, et al.
Human Molecular Genetics
|
March 4, 2016
mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome
Rocco G Gogliotti, Rebecca K Senter, Jerri M Rook, et al.
Bioorganic & Medicinal Chemistry Letters
|
September 2, 2014
Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354
Wandong Wen, Summer E Young, Matthew T Duvernay, et al.
Neuropharmacology
|
July 22, 2017
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M<sub>4</sub> PAM VU0467154
Robert W Gould, Michael D Grannan, Barak W Gunter, et al.
Journal of Medicinal Chemistry
|
January 5, 2019
Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu<sub>7</sub> Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1 H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962)
Carson W Reed, Samantha E Yohn, Jordan P Washecheck, et al.
Plos One
|
October 5, 2011
Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding
Nicole Speed, Christine Saunders, Adeola R Davis, et al.
ACS Chemical Biology
|
August 20, 2014
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics
Hyekyung P Cho, Pedro M Garcia-Barrantes, John T Brogan, et al.
Page
of 57
Search research articles
Search
Showing results (411-420 of 570) with videos related to
Sort By:
Page
of 57
ACS Medicinal Chemistry Letters
|
September 28, 2018
VU6007477, a Novel M<sub>1</sub> PAM Based on a Pyrrolo[2,3-<i>b</i>]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events
Julie L Engers, Elizabeth S Childress, Madeline F Long, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|
March 28, 2018
M<sub>1</sub>-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition
Sean P Moran, Jonathan W Dickerson, Hyekyung P Cho, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
October 2, 2014
Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration
Daisuke Tsugawa, Yuki Oya, Ryota Masuzaki, et al.
Journal of Medicinal Chemistry
|
November 26, 2014
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)
Lindsey C Morris, Kellie D Nance, Patrick R Gentry, et al.
Human Molecular Genetics
|
March 4, 2016
mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome
Rocco G Gogliotti, Rebecca K Senter, Jerri M Rook, et al.
Bioorganic & Medicinal Chemistry Letters
|
September 2, 2014
Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354
Wandong Wen, Summer E Young, Matthew T Duvernay, et al.
Neuropharmacology
|
July 22, 2017
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M<sub>4</sub> PAM VU0467154
Robert W Gould, Michael D Grannan, Barak W Gunter, et al.
Journal of Medicinal Chemistry
|
January 5, 2019
Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu<sub>7</sub> Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1 H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962)
Carson W Reed, Samantha E Yohn, Jordan P Washecheck, et al.
Plos One
|
October 5, 2011
Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding
Nicole Speed, Christine Saunders, Adeola R Davis, et al.
ACS Chemical Biology
|
August 20, 2014
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics
Hyekyung P Cho, Pedro M Garcia-Barrantes, John T Brogan, et al.
Page
of 57