Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Filters

W Lindsley

Showing results (431-440 of 570) with videos related to

Pageof 57
Sort By:
ACS Chemical Neuroscience|August 5, 2021
Identification of a Novel Allosteric Site at the M<sub>5</sub> Muscarinic Acetylcholine ReceptorWessel A C Burger, Patrick R Gentry, Alice E Berizzi, et al.
Journal of Medicinal Chemistry|September 25, 2018
Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu<sub>4</sub>)Sean R Bollinger, Darren W Engers, Joseph D Panarese, et al.
Molecular Pharmacology|May 2, 2009
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learningDouglas J Sheffler, Richard Williams, Thomas M Bridges, et al.
ACS Chemical Neuroscience|June 5, 2013
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in miceKristian Kaufmann, Ian Romaine, Emily Days, et al.
Molecular Pharmacology|August 7, 2012
Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationshipsKaren J Gregory, Meredith J Noetzel, Jerri M Rook, et al.
Bioorganic & Medicinal Chemistry Letters|May 15, 2018
The discovery of VU0486846: steep SAR from a series of M<sub>1</sub> PAMs based on a novel benzomorpholine coreJeanette L Bertron, Hyekyung P Cho, Pedro M Garcia-Barrantes, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 4, 2013
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanismThomas M Bridges, Jerri M Rook, Meredith J Noetzel, et al.
Molecular Psychiatry|August 18, 2018
Activation of the mGlu<sub>1</sub> metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M<sub>4</sub> muscarinic receptor allosteric modulatorsSamantha E Yohn, Daniel J Foster, Dan P Covey, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|November 26, 2009
Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cellsTodd W Miller, James T Forbes, Chirayu Shah, et al.
ACS Medicinal Chemistry Letters|May 14, 2025
Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor <i>in Vivo</i> Tool CompoundMotoyuki Tanaka, Takahiro Mori, Gakuji Hashimoto, et al.
Pageof 57

Showing results (431-440 of 570) with videos related to

Sort By:
Pageof 57
ACS Chemical Neuroscience|August 5, 2021
Identification of a Novel Allosteric Site at the M<sub>5</sub> Muscarinic Acetylcholine ReceptorWessel A C Burger, Patrick R Gentry, Alice E Berizzi, et al.
Journal of Medicinal Chemistry|September 25, 2018
Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu<sub>4</sub>)Sean R Bollinger, Darren W Engers, Joseph D Panarese, et al.
Molecular Pharmacology|May 2, 2009
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learningDouglas J Sheffler, Richard Williams, Thomas M Bridges, et al.
ACS Chemical Neuroscience|June 5, 2013
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in miceKristian Kaufmann, Ian Romaine, Emily Days, et al.
Molecular Pharmacology|August 7, 2012
Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationshipsKaren J Gregory, Meredith J Noetzel, Jerri M Rook, et al.
Bioorganic & Medicinal Chemistry Letters|May 15, 2018
The discovery of VU0486846: steep SAR from a series of M<sub>1</sub> PAMs based on a novel benzomorpholine coreJeanette L Bertron, Hyekyung P Cho, Pedro M Garcia-Barrantes, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 4, 2013
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanismThomas M Bridges, Jerri M Rook, Meredith J Noetzel, et al.
Molecular Psychiatry|August 18, 2018
Activation of the mGlu<sub>1</sub> metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M<sub>4</sub> muscarinic receptor allosteric modulatorsSamantha E Yohn, Daniel J Foster, Dan P Covey, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|November 26, 2009
Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cellsTodd W Miller, James T Forbes, Chirayu Shah, et al.
ACS Medicinal Chemistry Letters|May 14, 2025
Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor <i>in Vivo</i> Tool CompoundMotoyuki Tanaka, Takahiro Mori, Gakuji Hashimoto, et al.
Pageof 57