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W Lindsley

Showing results (441-450 of 570) with videos related to

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Journal of Medicinal Chemistry|December 13, 2012
Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL proteaseJon Jacobs, Valerie Grum-Tokars, Ya Zhou, et al.
Bioorganic & Medicinal Chemistry Letters|January 11, 2007
Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHAZhijian Zhao, David D Wisnoski, Julie A O'Brien, et al.
Molecular Pharmacology|June 14, 2018
Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992Sujay V Kharade, Haruto Kurata, Aaron M Bender, et al.
Bioorganic & Medicinal Chemistry Letters|September 21, 2011
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071Evan P Lebois, Gregory J Digby, Douglas J Sheffler, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|July 1, 2017
Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory ReconsolidationAdam G Walker, Douglas J Sheffler, Andrew S Lewis, et al.
ACS Medicinal Chemistry Letters|August 14, 2024
Discovery of VU6008677: A Structurally Distinct Tricyclic M<sub>4</sub> Positive Allosteric Modulator with Improved CYP450 ProfileRory A Capstick, Sean R Bollinger, Julie L Engers, et al.
ACS Chemical Neuroscience|October 1, 2011
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous systemEvan P Lebois, Thomas M Bridges, L Michelle Lewis, et al.
Chemmedchem|April 3, 2014
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probePatrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|May 2, 2016
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacyRocco D Gogliotti, Darren W Engers, Pedro M Garcia-Barrantes, et al.
Bioorganic & Medicinal Chemistry Letters|June 29, 2012
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptorJames M Salovich, Paige N Vinson, Douglas J Sheffler, et al.
Pageof 57

Showing results (441-450 of 570) with videos related to

Sort By:
Pageof 57
Journal of Medicinal Chemistry|December 13, 2012
Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL proteaseJon Jacobs, Valerie Grum-Tokars, Ya Zhou, et al.
Bioorganic & Medicinal Chemistry Letters|January 11, 2007
Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHAZhijian Zhao, David D Wisnoski, Julie A O'Brien, et al.
Molecular Pharmacology|June 14, 2018
Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992Sujay V Kharade, Haruto Kurata, Aaron M Bender, et al.
Bioorganic & Medicinal Chemistry Letters|September 21, 2011
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071Evan P Lebois, Gregory J Digby, Douglas J Sheffler, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|July 1, 2017
Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory ReconsolidationAdam G Walker, Douglas J Sheffler, Andrew S Lewis, et al.
ACS Medicinal Chemistry Letters|August 14, 2024
Discovery of VU6008677: A Structurally Distinct Tricyclic M<sub>4</sub> Positive Allosteric Modulator with Improved CYP450 ProfileRory A Capstick, Sean R Bollinger, Julie L Engers, et al.
ACS Chemical Neuroscience|October 1, 2011
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous systemEvan P Lebois, Thomas M Bridges, L Michelle Lewis, et al.
Chemmedchem|April 3, 2014
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probePatrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|May 2, 2016
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacyRocco D Gogliotti, Darren W Engers, Pedro M Garcia-Barrantes, et al.
Bioorganic & Medicinal Chemistry Letters|June 29, 2012
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptorJames M Salovich, Paige N Vinson, Douglas J Sheffler, et al.
Pageof 57