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Proceedings of the National Academy of Sciences of the United States of America|October 29, 2015
Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 miceTristano Pancani, Daniel J Foster, Mark S Moehle, et al.
Bioorganic & Medicinal Chemistry Letters|July 1, 2018
Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu<sub>4</sub> positive allosteric modulators that mitigate CYP1A2 induction liabilityDarren W Engers, Sean R Bollinger, Julie L Engers, et al.
Bioorganic & Medicinal Chemistry Letters|May 22, 2012
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAMDouglas J Sheffler, Cody J Wenthur, Joshua A Bruner, et al.
The Journal of Pharmacology and Experimental Therapeutics|December 21, 2004
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral modelsGene G Kinney, Julie A O'Brien, Wei Lemaire, et al.
Bioorganic & Medicinal Chemistry Letters|November 13, 2012
Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffoldAlice L Rodriguez, Ya Zhou, Richard Williams, et al.
Journal of Medicinal Chemistry|September 4, 2015
Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in RodentsJulie L Engers, Alice L Rodriguez, Leah C Konkol, et al.
Bioorganic & Medicinal Chemistry Letters|July 18, 2015
Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compoundYa Zhou, Chrysa Malosh, Susana Conde-Ceide, et al.
Proceedings of the National Academy of Sciences of the United States of America|November 28, 2019
Crystal structure of the M<sub>5</sub> muscarinic acetylcholine receptorZiva Vuckovic, Patrick R Gentry, Alice E Berizzi, et al.
ACS Medicinal Chemistry Letters|October 24, 2017
Discovery of VU6005649, a CNS Penetrant mGlu<sub>7/8</sub> Receptor PAM Derived from a Series of Pyrazolo[1,5-<i>a</i>]pyrimidinesMasahito Abe, Mabel Seto, Rocco G Gogliotti, et al.
Bioorganic & Medicinal Chemistry Letters|October 28, 2021
Discovery of structurally distinct tricyclic M<sub>4</sub> positive allosteric modulator (PAM) chemotypes - Part 2Madeline F Long, Rory A Capstick, Paul K Spearing, et al.
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