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Platelets|December 19, 2018
Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactionsRachel A Rigg, Laura D Healy, Tiffany T Chu, et al.
Bioorganic & Medicinal Chemistry Letters|November 27, 2012
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophreniaUyen Le, Bruce J Melancon, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|June 26, 2014
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiencyMark Turlington, Meredith J Noetzel, Thomas M Bridges, et al.
ACS Chemical Neuroscience|June 23, 2026
Discovery of VU6066098: A Selective and CNS-Penetrant mGlu<sub>2</sub> NAM with Robust Antidepressant-, Antipsychotic-, and Procognitive-like Activity in RodentsJeremy S Coleman, Rory A Capstick, Sichen Chang, et al.
ACS Medicinal Chemistry Letters|December 21, 2017
VU6010608, a Novel mGlu<sub>7</sub> NAM from a Series of <i>N</i>-(2-(1<i>H</i>-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamidesCarson W Reed, Kevin M McGowan, Paul K Spearing, et al.
Journal of Medicinal Chemistry|October 5, 2011
Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal modelCarrie K Jones, Darren W Engers, Analisa D Thompson, et al.
Molecular Pharmacology|March 5, 2022
VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium ChannelsSamantha J McClenahan, Caitlin N Kent, Sujay V Kharade, et al.
Molecular Pharmacology|December 3, 2008
Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activityJoy E Marlo, Colleen M Niswender, Emily L Days, et al.
Bioorganic & Medicinal Chemistry Letters|August 1, 2016
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in dispositionMichael R Wood, Meredith J Noetzel, James C Tarr, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|June 26, 2015
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse ModelA Ghoshal, J M Rook, J W Dickerson, et al.
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