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Proceedings of the National Academy of Sciences of the United States of America|January 17, 2023
A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm functionMaximilian Lyon, Ping Li, Juan J Ferreira, et al.
ACS Chemical Neuroscience|November 23, 2012
Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169James C Tarr, Mark L Turlington, Paul R Reid, et al.
Journal of Medicinal Chemistry|September 21, 2013
Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254)Mark Turlington, Meredith J Noetzel, Aspen Chun, et al.
ACS Chemical Neuroscience|September 24, 2024
Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M<sub>4</sub> Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)Julie L Engers, Logan A Baker, Sichen Chang, et al.
Molecular Pharmacology|July 31, 2008
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4Colleen M Niswender, Kari A Johnson, C David Weaver, et al.
ACS Chemical Neuroscience|April 28, 2018
A Novel M<sub>1</sub> PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic ToxicityJerri M Rook, Jeanette L Bertron, Hyekyung P Cho, et al.
The Journal of Biological Chemistry|October 4, 2012
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmiasFranck Potet, Amanda N Lorinc, Sebastien Chaigne, et al.
Bioorganic & Medicinal Chemistry Letters|December 18, 2007
Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)Zhijian Zhao, Scott E Wolkenberg, Philip E J Sanderson, et al.
Bioorganic & Medicinal Chemistry Letters|May 20, 2017
Challenges in the development of an M<sub>4</sub> PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amidesJames C Tarr, Michael R Wood, Meredith J Noetzel, et al.
ACS Chemical Neuroscience|December 22, 2016
Diverse Effects on M<sub>1</sub> Signaling and Adverse Effect Liability within a Series of M<sub>1</sub> Ago-PAMsJerri M Rook, Masahito Abe, Hyekyung P Cho, et al.
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