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ACS Medicinal Chemistry Letters|July 16, 2025
Discovery of a Novel sp<sup>3</sup>‑Rich M<sub>1</sub> Positive Allosteric Modulators (PAMs) Chemotype via Scaffold HoppingJoseph D Bungard, Paul Spearing, Yu Nishio, et al.
ACS Chemical Neuroscience|April 15, 2016
Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4)Darren W Engers, Anna L Blobaum, Rocco D Gogliotti, et al.
Biological Psychiatry|November 13, 2012
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activityJerri M Rook, Meredith J Noetzel, Wendy A Pouliot, et al.
Bioorganic & Medicinal Chemistry Letters|September 5, 2006
Potent antagonists of the Kv1.5 potassium channel: synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamidesKausik K Nanda, M Brad Nolt, Matthew J Cato, et al.
ACS Medicinal Chemistry Letters|August 20, 2021
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M<sub>4</sub> Muscarinic Acetylcholine Receptor AntagonistMatthew Spock, Trever R Carter, Katrina A Bollinger, et al.
Bioorganic & Medicinal Chemistry Letters|September 18, 2012
Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossoverJason T Manka, Paige N Vinson, Karen J Gregory, et al.
ACS Chemical Neuroscience|August 28, 2024
Discovery of VU6007496: Challenges in the Development of an M<sub>1</sub> Positive Allosteric Modulator Backup CandidateJulie L Engers, Katrina A Bollinger, Rory A Capstick, et al.
Bioorganic & Medicinal Chemistry Letters|November 2, 2017
Challenges in the development of an M<sub>4</sub> PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amidesJames C Tarr, Michael R Wood, Meredith J Noetzel, et al.
ACS Chemical Neuroscience|March 25, 2025
Application of Deuterium in an M<sub>1</sub> Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422Julie L Engers, Jinming Li, Changho Han, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|October 10, 2008
Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in ratsCarrie K Jones, Ashley E Brady, Albert A Davis, et al.
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