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Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|January 21, 2014
Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100Nellie E Byun, Michael Grannan, Michael Bubser, et al.
ACS Chemical Neuroscience|February 5, 2025
Further Optimization of the mGlu<sub>1</sub> PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
Elife|May 30, 2023
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamicsZiva Vuckovic, Jinan Wang, Vi Pham, et al.
ACS Medicinal Chemistry Letters|March 21, 2019
Discovery of VU2957 (Valiglurax): An mGlu<sub>4</sub> Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's DiseaseJoseph D Panarese, Darren W Engers, Yong-Jin Wu, et al.
Bioorganic & Medicinal Chemistry Letters|February 17, 2015
Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)María Luz Martín-Martín, José Manuel Bartolomé-Nebreda, Susana Conde-Ceide, et al.
ACS Chemical Neuroscience|November 26, 2025
Discovery of VU6052254: A Novel, Potent M<sub>1</sub> Positive Allosteric ModulatorJulie L Engers, Joseph D Bungard, Christopher C Presley, et al.
Journal of Medicinal Chemistry|August 6, 2024
Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M<sub>5</sub> Muscarinic Acetylcholine ReceptorJinming Li, Douglas L Orsi, Julie L Engers, et al.
ACS Pharmacology & Translational Science|August 23, 2021
Discovery of the First Selective M<sub>4</sub> Muscarinic Acetylcholine Receptor Antagonists with <i>in Vivo</i> Antiparkinsonian and Antidystonic EfficacyMark S Moehle, Aaron M Bender, Jonathan W Dickerson, et al.
ACS Medicinal Chemistry Letters|February 16, 2017
Discovery of VU0467485/AZ13713945: An M<sub>4</sub> PAM Evaluated as a Preclinical Candidate for the Treatment of SchizophreniaMichael R Wood, Meredith J Noetzel, Bruce J Melancon, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|June 20, 2012
The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5Ryan D Morrison, Anna L Blobaum, Frank W Byers, et al.
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