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Bioorganic & Medicinal Chemistry Letters|May 23, 2019
VU6005806/AZN-00016130, an advanced M<sub>4</sub> positive allosteric modulator (PAM) profiled as a potential preclinical development candidateDarren W Engers, Bruce J Melancon, Allison R Gregro, et al.
Bioorganic & Medicinal Chemistry Letters|October 18, 2015
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulatorsChrysa Malosh, Mark Turlington, Thomas M Bridges, et al.
ACS Chemical Neuroscience|January 26, 2026
Discovery of 7-(Pyridin-3-yl)thieno[3,2-<i>b</i>]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5Scott H Henderson, Anna E Ringuette, David L Whomble, et al.
ACS Medicinal Chemistry Letters|December 18, 2024
Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, et al.
Journal of Medicinal Chemistry|December 12, 2024
Discovery of VU6024578/BI02982816: An mGlu<sub>1</sub> Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition ModelsCarson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
ACS Chemical Neuroscience|September 17, 2014
Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7Nidhi Jalan-Sakrikar, Julie R Field, Rebecca Klar, et al.
Proceedings of the National Academy of Sciences of the United States of America|September 1, 2009
Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiationLei Ma, Matthew A Seager, Matthew Seager, et al.
ACS Pharmacology & Translational Science|September 19, 2025
Highly Potent and Subtype-Selective Sperm-Specific Potassium Channel SLO3 Inhibitors Display High Tissue Exposure in the Murine Female Reproductive TractKayla J Temple, Ping Li, Hallie G McKinnie, et al.
Bioorganic & Medicinal Chemistry Letters|January 30, 2017
Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokineticsScott E Wolkenberg, M Brad Nolt, Mark T Bilodeau, et al.
ACS Medicinal Chemistry Letters|July 10, 2015
Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting SchizophreniaSusana Conde-Ceide, Carlos M Martínez-Viturro, Jesús Alcázar, et al.
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